Understanding the Role of Chemokines and Cytokines in Experimental Models of Herpes Simplex Keratitis

Herpes simplex keratitis is a disease of the cornea caused by HSV-1. It is a leading cause of corneal blindness in the world. Underlying molecular mechanism is still unknown, but experimental models have helped give a better understanding of the underlying molecular pathology. Cytokines and chemokin...

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Bibliographic Details
Published in:Journal of immunology research 2017-01, Vol.2017 (2017), p.1-5
Main Authors: Azher, Tayaba N., Stuart, Patrick M., Yin, Xiao-Tang
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Chemokine CCL2 - immunology
Chemokines
Chemokines - immunology
Chemokines - metabolism
Cornea
Cornea - physiopathology
Cornea - virology
Corneal Neovascularization
Cytokines
Cytokines - immunology
Cytokines - metabolism
Disease Models, Animal
Herpes viruses
Herpesviridae
Herpesvirus 1, Human - isolation & purification
Herpesvirus 1, Human - physiology
Humans
Immunology
Infections
Inflammation
Interleukin-10 - immunology
Interleukin-17 - immunology
Interleukin-6 - immunology
Keratitis, Herpetic - immunology
Keratitis, Herpetic - virology
Lymphocytes
Mice
Neutrophil Infiltration
Neutrophils
Proteins
Review
Rodents
Studies
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Summary:Herpes simplex keratitis is a disease of the cornea caused by HSV-1. It is a leading cause of corneal blindness in the world. Underlying molecular mechanism is still unknown, but experimental models have helped give a better understanding of the underlying molecular pathology. Cytokines and chemokines are small proteins released by cells that play an important proinflammatory or anti-inflammatory role in modulating the disease process. Cytokines such as IL-17, IL-6, IL-1α, and IFN-γ and chemokines such as MIP-2, MCP-1, MIP-1α, and MIP-1β have proinflammatory role in the destruction caused by HSV including neutrophil infiltration and corneal inflammation, and other chemokines and cytokines such as IL-10 and CCL3 can have a protective role. Most of the damage results from neutrophil infiltration and neovascularization. While many more studies are needed to better understand the role of these molecules in both experimental models and human corneas, current studies indicate that these molecules hold potential to be targets of future therapy.
ISSN:2314-8861
2314-7156
DOI:10.1155/2017/7261980