Effectiveness of trichloroacetic acid and trichloroacetic acid with gel foam for closure in patients with central perforation of tympanic membrane—a randomized controlled trial

Background The tympanic membrane (TM) forms the partition between the external auditory canal and the middle ear. Perforations occur as a result of acute otitis media or traumatic causes which undergoes healing spontaneously over 3 to 4 weeks. Non-surgical methods are successful in the closure of sm...

Full description

Saved in:
Bibliographic Details
Published in:The Egyptian journal of otolaryngology 2023-12, Vol.39 (1), p.191-6, Article 191
Main Authors: Namasivaya Navin, R. B., Gowthame, K., Dhanasekaran, Balaji, Prabakaran, S., Rajasekaran, S., Sarath Kumar, B., Ramya Shree, C., Karthika, S. R.
Format: Article
Language:English
Subjects:
Acids
Age
Audiometry
Cauterization
Ear diseases
Eardrum
Ears & hearing
Endoscopy
Gel foam
Gender
Hearing loss
Histamine
Medicine
Medicine & Public Health
Original Article
Otolaryngology
Silver nitrate
Statistical analysis
Surgery
Trichloroacetic acid
Tympanic membrane
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The tympanic membrane (TM) forms the partition between the external auditory canal and the middle ear. Perforations occur as a result of acute otitis media or traumatic causes which undergoes healing spontaneously over 3 to 4 weeks. Non-surgical methods are successful in the closure of small to medium-sized perforations. Chemicals used for the cauterization of the margins of perforation are trichloroacetic acid and silver nitrate. This study was performed in a total of 90 patients. External auditory canal, tympanic membrane, site and size of perforation, and middle ear mucosa status were assessed followed by pure tone audiometry. One group constituting 45 subjects underwent TCA cauterization under sterile precautions. Another group of 45 subjects underwent the same procedure with TCA cautery and gel foam application for perforation closure. The procedure was repeated once a week for about 6 weeks. The effectiveness of these two procedures was compared between the two groups after a waiting period of 2 weeks. Results The mean age of the study population is 41.84 ± 16.71. Of the 90 study participants, 54.4% ( N  = 49) were less than 40 years of age, gender, cause, and laterality of perforation were not associated with the outcome whereas the size of the perforation was significantly associated with the closure of TM perforation with chi-square value of 7.028 and P value of 0.008 (
ISSN:2090-8539
1012-5574
2090-8539
DOI:10.1186/s43163-023-00556-3