Estrogen Receptor Beta (ERβ) Maintains Mitochondrial Network Regulating Invasiveness in an Obesity-Related Inflammation Condition in Breast Cancer

Obesity, a physiological situation where different proinflammatory cytokines and hormones are secreted, is a major risk factor for breast cancer. Mitochondrial functionality exhibits a relevant role in the tumorigenic potential of a cancer cell. In the present study, it has been examined the influen...

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Bibliographic Details
Published in:Antioxidants 2021-08, Vol.10 (9), p.1371
Main Authors: Martinez-Bernabe, Toni, Sastre-Serra, Jorge, Ciobu, Nicolae, Oliver, Jordi, Pons, Daniel Gabriel, Roca, Pilar
Format: Article
Language:English
Subjects:
17β-Estradiol
Adipocytes
Angiogenesis
Antibiotics
Antioxidants
Apoptosis
Biosynthesis
Breast cancer
Cell division
Cell growth
Cytokines
epithelial-to-mesenchymal transition (EMT)
estrogen receptor beta (ERβ)
Estrogen receptors
Estrogens
Inflammation
Interleukin 6
Interleukin 6 receptors
Invasiveness
Isoforms
Leptin
Medical prognosis
Metastasis
Mitochondria
mitochondrial biogenesis
mitochondrial dynamics
Morphology
Obesity
obesity-related inflammation
Oxidative stress
Patients
Penicillin
Phenols
Post-menopause
Precision medicine
Risk factors
Tumor cell lines
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Tumorigenesis
Tumors
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Summary:Obesity, a physiological situation where different proinflammatory cytokines and hormones are secreted, is a major risk factor for breast cancer. Mitochondrial functionality exhibits a relevant role in the tumorigenic potential of a cancer cell. In the present study, it has been examined the influence of an obesity-related inflammation ELIT treatment (17β-estradiol, leptin, IL-6, and TNFα), which aims to stimulate the hormonal conditions of a postmenopausal obese woman on the mitochondrial functionality and invasiveness of MCF7 and T47D breast cancer cell lines, which display a different ratio of both estrogen receptor isoforms, ERα and ERβ. The results showed a decrease in mitochondrial functionality, with an increase in oxidative stress and invasiveness and motility, in the MCF7 cell line (high ERα/ERβ ratio) compared to a maintained status in the T47D cell line (low ERα/ERβ ratio) after ELIT treatment. In addition, breast cancer biopsies were analyzed, showing that breast tumors of obese patients present a high positive correlation between IL-6 receptor and ERβ and have an increased expression of cytokines, antioxidant enzymes, and mitochondrial biogenesis and dynamics genes. Altogether, giving special importance to ERβ in the pathology of obese patients with breast cancer is necessary, approaching to personalized medicine.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10091371