In vivo comparison of dl-sotalol-induced electrocardiographic responses among halothane anesthesia, isoflurane anesthesia with nitrous oxide, and conscious state

We compared dl-sotalol-induced electrocardiographic responses in intact dogs using a repeated-measures design among 1% halothane anesthesia, 1.5% isoflurane anesthesia with nitrous oxide (N2O), and conscious state to clarify influences of the anesthetics (n = 4). Basal PR interval was longer in halo...

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Published in:Journal of pharmacological sciences 2021-01, Vol.145 (1), p.16-22
Main Authors: Saito, Hiroyuki, Kambayashi, Ryuichi, Hagiwara-Nagasawa, Mihoko, Nunoi, Yoshio, Goto, Ai, Izumi-Nakaseko, Hiroko, Kawai, Shinichi, Takei, Yoshinori, Matsumoto, Akio, Hoshiai, Kiyotaka, Akie, Yasuki, Sugiyama, Atsushi
Format: Article
Language:English
Subjects:
Anesthesia - methods
Animals
Consciousness - drug effects
Consciousness - physiology
dl-sotalol
Dogs
Electrocardiography - drug effects
Halothane
Halothane - pharmacology
Isoflurane
Isoflurane - pharmacology
Male
Nitrous oxide
Nitrous Oxide - pharmacology
QT interval
Sotalol - pharmacology
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Summary:We compared dl-sotalol-induced electrocardiographic responses in intact dogs using a repeated-measures design among 1% halothane anesthesia, 1.5% isoflurane anesthesia with nitrous oxide (N2O), and conscious state to clarify influences of the anesthetics (n = 4). Basal PR interval was longer in halothane than either in isoflurane with N2O or in conscious state, reflecting sympathetic nerve suppression for the atrioventricular node by halothane. Both anesthetics exhibited longer basal QRS width than conscious state, suggesting their ventricular INa inhibition. Also, both anesthetics showed longer basal QT interval, QTcF and Tpeak-Tend than conscious state, indicating their ventricular IKr inhibition. Meanwhile, dl-sotalol prolonged PR interval similarly in isoflurane with N2O and in conscious state, which was less great in halothane, suggesting further sympathetic nerve suppression for the atrioventricular node might be limited in halothane. dl-Sotalol prolonged QT interval and QTcF >3 times greater in either of the anesthetics than in conscious state; moreover, dl-sotalol prolonged Tpeak-Tend similarly in both anesthetics, but hardly altered it in conscious state; indicating isoflurane with N2O as well as halothane may have reduced the repolarization reserve to increase the sensitivity of ventricle toward IKr suppression. Thus, isoflurane with nitrous oxide could be useful for in vivo IKr assay like halothane.
ISSN:1347-8613
1347-8648
DOI:10.1016/j.jphs.2020.10.001