Recent Advances on the Production of Itaconic Acid via the Fermentation and Metabolic Engineering

Itaconic acid (ITA) is one of the top 12 platform chemicals. The global ITA market is expanding due to the rising demand for bio-based unsaturated polyester resin and its non-toxic qualities. Although bioconversion using microbes is the main approach in the current industrial production of ITA, ecol...

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Bibliographic Details
Published in:Fermentation (Basel) 2023-01, Vol.9 (1), p.71
Main Authors: Zhang, Renwei, Liu, Huan, Ning, Yuchen, Yu, Yue, Deng, Li, Wang, Fang
Format: Article
Language:English
Subjects:
Acids
Aspergillus terreus
Bioconversion
Biodiesel fuels
biosensor
Biosynthesis
Carbon
Catalysis
Cellulase
Chemical synthesis
Dehydrogenases
Engineering
Fermentation
Food waste
Glucose
Glycerol
Industrial production
Itaconic acid
Lignocellulose
Metabolic engineering
Metabolism
Metabolites
Production costs
Proteins
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Summary:Itaconic acid (ITA) is one of the top 12 platform chemicals. The global ITA market is expanding due to the rising demand for bio-based unsaturated polyester resin and its non-toxic qualities. Although bioconversion using microbes is the main approach in the current industrial production of ITA, ecological production of bio-based ITA faces several issues due to: low production efficiency, the difficulty to employ inexpensive raw materials, and high manufacturing costs. As metabolic engineering advances, the engineering of microorganisms offers a novel strategy for the promotion of ITA bio-production. In this review, the most recent developments in the production of ITA through fermentation and metabolic engineering are compiled from a variety of perspectives, including the identification of the ITA synthesis pathway, the metabolic engineering of natural ITA producers, the design and construction of the ITA synthesis pathway in model chassis, and the creation, as well as application, of new metabolic engineering strategies in ITA production. The challenges encountered in the bio-production of ITA in microbial cell factories are discussed, and some suggestions for future study are also proposed, which it is hoped offers insightful views to promote the cost-efficient and sustainable industrial production of ITA.
ISSN:2311-5637
2311-5637
DOI:10.3390/fermentation9010071