Exploring the Novel Dimension of Immune Interactions in Pain: JAK Inhibitors’ Pleiotropic Potential

This review explores the link between immune interactions and chronic pain, offering new perspectives on treatment. It focuses on Janus kinase (JAK) inhibitors’ potential in pain management. Immune cells’ communication with neurons shapes neuroinflammatory responses, and JAK inhibitors’ effects on p...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2023-09, Vol.13 (10), p.1994
Main Authors: Kraev, Krasimir, Geneva-Popova, Mariela, Hristov, Bozhidar, Uchikov, Petar, Popova, Stanislava, Kraeva, Maria, Basheva-Kraeva, Yordanka, Sheytanov, Ivan, Petranova, Tzvetanka, Stoyanova, Nina, Atanassov, Marin
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Cell interactions
Chemokines
Chronic pain
Cytokines
Growth factors
Immune response
Immune system
Immunology
Inflammation
Inhibitors
JAK inhibitors
Janus kinase
Kinases
Lymphocytes
Neurobiology
neurobiology of pain
Neurons
Neurosciences
Neutrophils
Optimization
Pain
Psoriatic arthritis
Review
Reviews
Rheumatic diseases
Rheumatoid arthritis
Spinal cord
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Summary:This review explores the link between immune interactions and chronic pain, offering new perspectives on treatment. It focuses on Janus kinase (JAK) inhibitors’ potential in pain management. Immune cells’ communication with neurons shapes neuroinflammatory responses, and JAK inhibitors’ effects on pain pathways are discussed, including cytokine suppression and microglial modulation. This review integrates studies from rheumatoid arthritis (RA) pain and central sensitization to highlight connections between immune interactions and pain. Studies on RA joint pain reveal the shift from cytokines to sensitization. Neurobiological investigations into central sensitization uncover shared pathways in chronic pain. Clinical evidence supports JAK inhibitors’ efficacy on pain-related outcomes and their effects on neurons and immune cells. Challenges and future directions are outlined, including interdisciplinary collaboration and dosing optimization. Overall, this review highlights JAK inhibitors’ potential to target immune-mediated pain pathways, underscoring the need for more research on immune–pain connections.
ISSN:2075-1729
2075-1729
DOI:10.3390/life13101994