Significance of genetic polymorphisms in long non-coding RNA AC079767.4 in tuberculosis susceptibility and clinical phenotype in Western Chinese Han population

Recent studies have implicated long non-coding RNA, AC079767 . 4 , as a highly susceptible gene in tuberculosis. The aim of the study was to preliminarily explore the possible association of single nucleotide polymorphisms (SNPs) in AC079767 . 4 gene with clinical phenotypes and TB susceptibility in...

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Bibliographic Details
Published in:Scientific reports 2017-04, Vol.7 (1), p.965-11, Article 965
Main Authors: Zhao, Zhenzhen, Zhang, Mei, Ying, Jun, Hu, Xuejiao, Zhang, Jingya, Zhou, Yanhong, Zhou, Yi, Song, Xingbo, Ying, Binwu
Format: Article
Language:English
Subjects:
45
45/22
45/77
631/326/2521
631/337/384/2568
631/45/881
Alleles
Fever
Haplotypes
Humanities and Social Sciences
multidisciplinary
Non-coding RNA
Polymorphism
Population studies
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
Therapeutic applications
Tuberculosis
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Summary:Recent studies have implicated long non-coding RNA, AC079767 . 4 , as a highly susceptible gene in tuberculosis. The aim of the study was to preliminarily explore the possible association of single nucleotide polymorphisms (SNPs) in AC079767 . 4 gene with clinical phenotypes and TB susceptibility in Western Chinese Han population. The improved multiplex ligation detection reaction (iMLDR) method was employed to genotype 4 SNPs in AC079767 . 4 in 554 tuberculosis patients and 561 healthy individuals. In subgroup analysis, only the C allele for rs12477677 was associated with the decreased susceptibility to pulmonary TB with a p -value of 0.026, but p -value was 0.103 after Bonferroni correction. In total samples, haplotype [ACAC], representing four AC079767 . 4 variants, was found to slightly decrease TB risk ( p  = 0.045). Furthermore, patients with the CC genotype of rs12477677 were correlated with fewer occurrences of fever ( p  = 0.016), while patients carrying the T allele were associated with lower levels of ESR in the dominant model of rs1055229 ( p  = 0.021). For the first time, we reported the potential susceptibility and clinical traits of tuberculosis with lncRNA variants in the Western Han Chinese population. Our data indicate AC079767 . 4 polymorphisms may potentially act as novel biomarkers for tuberculosis diagnostic and therapeutic purposes.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-01163-y