Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy

To investigate predictors of navigated subthreshold micropulse laser (SML) treatment in chronic central serous chorioretinopathy (cCSC). In this single-center prospective consecutive case series, patients with cCSC were treated with 577 nm SML and followed up for 12 months. A complete ophthalmologic...

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Bibliographic Details
Published in:BMC ophthalmology 2024-11, Vol.24 (1), p.478-7, Article 478
Main Authors: Iovino, Claudio, Iodice, Clemente Maria, Damiano, Luciana, Pisani, Danila, Testa, Francesco, Rossi, Settimio, Simonelli, Francesca
Format: Article
Language:English
Subjects:
Acuity
Adult
Angiography
Central Serous Chorioretinopathy - diagnosis
Central Serous Chorioretinopathy - physiopathology
Central Serous Chorioretinopathy - surgery
Chronic central serous chorioretinopathy
Chronic Disease
Cysts
Evidence-based medicine
Female
Fluorescein
Fluorescein angiography
Fluorescein Angiography - methods
Follow-Up Studies
Fundus Oculi
Humans
Laser Coagulation - methods
Lasers
Male
Medical imaging
Medical research
Medicine, Experimental
Middle Aged
Morphology
Optical coherence tomography
Political aspects
Predictors
Prospective Studies
Retinal detachment
Statistical analysis
Subretinal Fluid
Subthreshold micropulse laser
Success
Tomography, Optical Coherence - methods
Verteporfin
Visual Acuity - physiology
Visual Field Tests - methods
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Summary:To investigate predictors of navigated subthreshold micropulse laser (SML) treatment in chronic central serous chorioretinopathy (cCSC). In this single-center prospective consecutive case series, patients with cCSC were treated with 577 nm SML and followed up for 12 months. A complete ophthalmological evaluation including spectral optical coherence tomography (SD-OCT), fluorescein angiography (FA) and microperimetry (MP) was performed. FA hyperfluorescence patterns and SD-OCT features were investigated. Overall, 38 eyes from 38 patients affected by cCSC with a mean age of 48.20 ± 5.95 years were included. Thirty-one eyes (81.6%) demonstrated a significant subretinal fluid (SRF) reduction after treatment at 3 months. Complete SRF resolution was achieved by twenty-three patients (60.5%) at 3 months and attained by an additional patient (24 in total, 63.2%) at 6 months. Twenty-two (57.9%) of such individuals were confirmed with no SRF at the end of the follow-up. Best-corrected visual acuity improved significantly and progressively at all timepoints from baseline, in parallel with macular sensitivity (all p:
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-024-03711-3