Glaucoma and Antioxidants: Review and Update

Glaucoma is a neurodegenerative disease characterised by the progressive degeneration of retinal ganglion cells. Oxidative stress has been related to the cell death in this disease. Theoretically, this deleterious consequence can be reduced by antioxidants substances. The aim of this review is to as...

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Bibliographic Details
Published in:Antioxidants 2020-10, Vol.9 (11), p.1031
Main Authors: Garcia-Medina, Jose Javier, Rubio-Velazquez, Elena, Lopez-Bernal, Maria Dolores, Cobo-Martinez, Alejandro, Zanon-Moreno, Vicente, Pinazo-Duran, Maria Dolores, del-Rio-Vellosillo, Monica
Format: Article
Language:English
Subjects:
Acids
Animal models
antioxidant
Antioxidants
Apoptosis
Cell death
Clinical trials
Glaucoma
Ischemia
Lipid peroxidation
Lipids
Neurodegeneration
Neurodegenerative diseases
Optic nerve
Oxidative stress
Pathophysiology
Physiological aspects
Retinal ganglion cells
Review
Supplements
Vitamin C
Vitamin E
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Description
Summary:Glaucoma is a neurodegenerative disease characterised by the progressive degeneration of retinal ganglion cells. Oxidative stress has been related to the cell death in this disease. Theoretically, this deleterious consequence can be reduced by antioxidants substances. The aim of this review is to assemble the studies published in relation to antioxidant supplementation and its effects on glaucoma and to offer the reader an update on this field. With this purpose, we have included studies in animal models of glaucoma and clinical trials. Although there are variable results, supplementation with antioxidants in glaucoma may be a promising therapy in glaucoma.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox9111031