The role of insulin-like growth factor 2 mRNA binding proteins in female reproductive pathophysiology

Insulin-like growth factor 2 (IGF2) mRNA binding proteins (IMPs) family belongs to a highly conserved family of RNA-binding proteins (RBPs) and is responsible for regulating RNA processing including localization, translation and stability. Mammalian IMPs (IMP1-3) take part in development, metabolism...

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Published in:Reproductive biology and endocrinology 2022-06, Vol.20 (1), p.89-89, Article 89
Main Authors: Xu, Xiao, Shen, Hao-Ran, Zhang, Jia-Rong, Li, Xue-Lian
Format: Article
Language:English
Subjects:
Binding proteins
Carcinogenesis
Cell division
Cell growth
Cell migration
Diabetes
Diabetes mellitus
Embryogenesis
Embryonic development
Embryos
Endometrium
Female reproductive system
Folliculogenesis
GDM
Genomes
IMP
Insulin
Insulin-like growth factor II
Insulin-like growth factors
Kinases
Localization
Mammals
Messenger RNA
Metabolism
mRNA
Obstetrics
Ovaries
Ovary
Pathogenesis
Pathophysiology
PCOS
Physiological aspects
Physiology
Polycystic ovary syndrome
Pre-eclampsia
Pregnancy
Protein binding
Proteins
Review
RNA processing
RNA-binding protein
Stein-Leventhal syndrome
Therapeutic targets
Tumorigenesis
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Summary:Insulin-like growth factor 2 (IGF2) mRNA binding proteins (IMPs) family belongs to a highly conserved family of RNA-binding proteins (RBPs) and is responsible for regulating RNA processing including localization, translation and stability. Mammalian IMPs (IMP1-3) take part in development, metabolism and tumorigenesis, where they are believed to play a major role in cell growth, metabolism, migration and invasion. IMPs have been identified that are expressed in ovary, placenta and embryo. The up-to-date evidence suggest that IMPs are involved in folliculogenesis, oocyte maturation, embryogenesis, implantation, and placentation. The dysregulation of IMPs not only contributes to carcinogenesis but also disturbs the female reproduction, and may participate in the pathogenesis of reproductive diseases and obstetric syndromes, such as polycystic ovary syndrome (PCOS), pre-eclampsia (PE), gestational diabetes mellitus (GDM) and gynecological tumors. In this review, we summarize the role of IMPs in female reproductive pathophysiology, and hope to provide new insights into the identification of potential therapeutic targets.
ISSN:1477-7827
1477-7827
DOI:10.1186/s12958-022-00960-z