Absence of meningeal mast cells in the Mitf mutant mouse

Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response . In this study, we illustrate that a mutation in microphthalmia-associated tra...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2024-02, Vol.18, p.1337621-1337621
Main Authors: Sabaté San José, Alba, Petersen, Petur Henry
Format: Article
Language:English
Subjects:
aging
Animals
Central nervous system
Immune response
Inflammation
Mast cells
Meninges
Microphthalmia-associated transcription factor
Mutation
Pathology
Transcription factors
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Summary:Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response . In this study, we illustrate that a mutation in microphthalmia-associated transcription factor ( ) affects meningeal MC number in a dosage-dependent manner. C57BL/6J null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. heterozygous mice might be a valuable tool to study the role of MCs in the meninges.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2024.1337621