The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma

Multiple Myeloma (MM) is a hematological malignancy with genomic heterogeneity and poor survival outcome. Apart from the central role of genetic lesions, epigenetic anomalies have been identified as drivers in the development of the disease. Alterations in the DNA methylome were mapped in 52 newly d...

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Bibliographic Details
Published in:Journal of hematology and oncology 2020-08, Vol.13 (1), p.108-15, Article 108
Main Authors: Choudhury, Samrat Roy, Ashby, Cody, Tytarenko, Ruslana, Bauer, Michael, Wang, Yan, Deshpande, Shayu, Den, Judith, Schinke, Carolina, Zangari, Maurizio, Thanendrarajan, Sharmilan, Davies, Faith E, van Rhee, Frits, Morgan, Gareth J, Walker, Brian A
Format: Article
Language:English
Subjects:
Aneuploidy
Arrays
Bone marrow
Cancer genetics
Chromatin
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 11 - ultrastructure
Chromosomes, Human, Pair 14 - genetics
Chromosomes, Human, Pair 14 - ultrastructure
Chromosomes, Human, Pair 4 - genetics
Chromosomes, Human, Pair 4 - ultrastructure
Comparative analysis
Consortia
Cyclin D1 - biosynthesis
Cyclin D1 - genetics
Cyclin D2 - biosynthesis
Cyclin D2 - genetics
Cytogenetics
Deoxyribonucleic acid
DNA
DNA Methylation
DNA, Neoplasm - genetics
DNA, Neoplasm - metabolism
Enhancers
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Epigenome
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Ontology
gene regulation
Gene Regulatory Networks - genetics
Genes
Genomes
Hematology
Histone Code
Histones - metabolism
Humans
Malignancy
Methylation
Multiple myeloma
Multiple Myeloma - classification
Multiple Myeloma - genetics
myeloma
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Oncology
Plasma cells
Plasma Cells - metabolism
Promoter Regions, Genetic
Proteins
Proto-Oncogene Proteins c-maf - genetics
Quality control
Software
Transcription (Genetics)
Translocation, Genetic
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Summary:Multiple Myeloma (MM) is a hematological malignancy with genomic heterogeneity and poor survival outcome. Apart from the central role of genetic lesions, epigenetic anomalies have been identified as drivers in the development of the disease. Alterations in the DNA methylome were mapped in 52 newly diagnosed MM (NDMM) patients of six molecular subgroups and matched with loci-specific chromatin marks to define their impact on gene expression. Differential DNA methylation analysis was performed using DMAP with a ≥10% increase (hypermethylation) or decrease (hypomethylation) in NDMM subgroups, compared to control samples, considered significant for all the subsequent analyses with p
ISSN:1756-8722
1756-8722
DOI:10.1186/s13045-020-00933-y