Balanced chromosomal translocation of chromosomes 6 and 7: a rare male factor of spontaneous abortions

Carriers of structural chromosomal rearrangements such as Robertsonian or reciprocal translocations have an increased risk of spontaneous abortion and producing offspring with genetic abnormalities. We report a man with balanced chromosomal translocations located at 6p22, and 7q22. His wife has a hi...

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Bibliographic Details
Published in:Balkan medical journal 2013-06, Vol.30 (2), p.250-252
Main Authors: Resim, Sefa, Kadıoğlu, Ateş, Akman, Tolga, Bayrak, Ayşe Gül, Efe, Erkan
Format: Article
Language:English
Subjects:
Balanced chromosomal translocation
Case Report
preimplantation genetic diagnosis
spontaneous abortions
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Summary:Carriers of structural chromosomal rearrangements such as Robertsonian or reciprocal translocations have an increased risk of spontaneous abortion and producing offspring with genetic abnormalities. We report a man with balanced chromosomal translocations located at 6p22, and 7q22. His wife has a history of four spontaneous abortions. Couples with a history of abortions should be investigated cytogenetically, after other causes of miscarriages are excluded. The possibility of spontaneous abortions can be reduced with preimplantation genetic diagnosis (PGD) before embryo transfer.
ISSN:2146-3123
2146-3131
DOI:10.5152/balkanmedj.2012.107