Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines

In the present study, in vitro neuronal cell cultures were exposed to the two most common varieties of EDCs reported in food, phthalates and bisphenol A (BPA). Specifically, Bis (2-ethylhexyl) phthalate (DEHP), Mono-butyl-phthalate (MBP), Di-n-octylphthalate (OP), and Bisphenol A (BPA) were exposed...

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Bibliographic Details
Published in:All life (Online) 2024-12, Vol.17 (1)
Main Authors: García-Cerón, Gabriela, Solano-González, Alba Fernanda, Bello-Cortés, Iván Hazael, Bonilla-Brunner, Ileana Andrea, Araiza-Olivera, Daniela, Gutiérrez-Aguilar, Manuel, Ramiro-Cortés, Yazmin, Rosetti, Marcos Francisco, García-Arrazola, Roeb
Format: Article
Language:English
Subjects:
bisphenol a (bpa)
endocrine disrupting compounds (edcs)
in vitro model
methionine synthase activity
phthalates
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Summary:In the present study, in vitro neuronal cell cultures were exposed to the two most common varieties of EDCs reported in food, phthalates and bisphenol A (BPA). Specifically, Bis (2-ethylhexyl) phthalate (DEHP), Mono-butyl-phthalate (MBP), Di-n-octylphthalate (OP), and Bisphenol A (BPA) were exposed in Neuro-2a neuroblastoma cell line. The enzymatic activity of methionine synthase (MS) was reduced by up to 3-fold in comparison to cultures that were not exposed to EDCs. MS is the key enzyme in the metabolic pathway that has been proposed elsewhere to be related to redox/methylation related disorders.
ISSN:2689-5293
2689-5307
DOI:10.1080/26895293.2024.2407213