Trace elements changes in the forebrain and their influence on the rats behavior in elevated plus maze in acute period of mild blast-induced traumatic brain injury

The relevance of the study is related to the high frequency of blast-induced brain injury in both military and civilian populations, which is caused by the use of various types of explosives in military conflicts, including in Ukraine today.  Changes of biometals in the acute period of a mild blast-...

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Bibliographic Details
Published in:Medychni perspektyvy 2023-06, Vol.28 (2), p.10-20
Main Author: Kozlova, Yu.V.
Format: Article
Language:English
Subjects:
behavior
blast-induced trauma
copper
elevated plus maze
forebrain
iron
zinc
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Summary:The relevance of the study is related to the high frequency of blast-induced brain injury in both military and civilian populations, which is caused by the use of various types of explosives in military conflicts, including in Ukraine today.  Changes of biometals in the acute period of a mild blast-induced traumatic brain injury, including forebrain that participates in the implementation of various behavioral and cognitive processes, remain unexplained. The study was carried out on 54 sexually mature male Wistar rats, which were divided into 3 groups: experimental (influenced by a baroacoustic wave with an excess pressure of 26-36 kPa, previously anesthetized with halothane and softly fixed), sham (under the influence of halothane and fixation), intact. Behavior was studied in an elevated plus maze. Biometals in the forebrain were determined using energy dispersive X-ray fluorescence analysis. Standard deviation, Mann-Whitney U test (р
ISSN:2307-0404
2786-4804
DOI:10.26641/2307-0404.2023.2.283151