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Executive functioning in alcoholics following an mHealth cognitive stimulation program: randomized controlled trial
The consequences of alcohol dependence are severe and may range from physical disease to neuropsychological deficits in several cognitive domains. Alcohol abuse has also been related to brain dysfunction specifically in the prefrontal cortex. Conventional neuropsychological interventions (paper-and-...
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| Published in: | Journal of medical Internet research 2014-04, Vol.16 (4), p.e102 |
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| container_issue | 4 |
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| creator | Gamito, Pedro Oliveira, Jorge Lopes, Paulo Brito, Rodrigo Morais, Diogo Silva, Diana Silva, Ana Rebelo, Sara Bastos, Marta Deus, Alberto |
| description | The consequences of alcohol dependence are severe and may range from physical disease to neuropsychological deficits in several cognitive domains. Alcohol abuse has also been related to brain dysfunction specifically in the prefrontal cortex. Conventional neuropsychological interventions (paper-and-pencil cognitive stimulation training) have a positive effect but are time-consuming, costly, and not motivating for patients.
Our goal was to test the cognitive effects of a novel approach to neuropsychological intervention, using mobile technology and serious games, on patients with alcohol dependence.
The trial design consisted of a two-arm study assessing the cognitive outcomes of neuropsychological intervention with mobile serious games (mHealth) versus control (treatment-as-usual with no neuropsychological intervention) in patients undergoing treatment for alcohol dependence syndrome. Sixty-eight patients were recruited from an alcohol-rehab clinic and randomly assigned to the mHealth (n=33) or control condition (n=35). The intervention on the experimental group consisted of a therapist-assisted cognitive stimulation therapy for 4 weeks on a 2-3 days/week basis.
Fourteen patients dropped out of the study. The results of the neuropsychological assessments with the remaining 54 patients showed an overall increase (P |
| doi_str_mv | 10.2196/jmir.2923 |
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Our goal was to test the cognitive effects of a novel approach to neuropsychological intervention, using mobile technology and serious games, on patients with alcohol dependence.
The trial design consisted of a two-arm study assessing the cognitive outcomes of neuropsychological intervention with mobile serious games (mHealth) versus control (treatment-as-usual with no neuropsychological intervention) in patients undergoing treatment for alcohol dependence syndrome. Sixty-eight patients were recruited from an alcohol-rehab clinic and randomly assigned to the mHealth (n=33) or control condition (n=35). The intervention on the experimental group consisted of a therapist-assisted cognitive stimulation therapy for 4 weeks on a 2-3 days/week basis.
Fourteen patients dropped out of the study. The results of the neuropsychological assessments with the remaining 54 patients showed an overall increase (P<.05) of general cognitive abilities, mental flexibility, psychomotor processing speed, and attentional ability in both experimental (n=26) and control groups (n=28). However, there was a more pronounced improvement (P=.01) specifically in frontal lobe functions from baseline (mean 13.89, SE 0.58) to follow-up (mean 15.50, SE 0.46) in the experimental group but not in the control group.
The overall increase in general cognitive function for both experimental and control groups supports the beneficial role of existing alcohol treatment protocols aimed at minimizing withdrawal symptoms, but the differential improvements observed in frontal lobe functioning supports the use of mobile serious games for neuropsychological stimulation to overcome executive dysfunction in patients with alcohol dependence. This trial was negative on two neuropsychological/cognitive tests, and positive on one.
ClinicalTrials.gov NCT01942954; http://www.clinicaltrials.gov/ct2/show/NCT01942954.</description><identifier>ISSN: 1438-8871</identifier><identifier>ISSN: 1439-4456</identifier><identifier>EISSN: 1438-8871</identifier><identifier>DOI: 10.2196/jmir.2923</identifier><identifier>PMID: 24742381</identifier><language>eng</language><publisher>Canada: Journal of Medical Internet Research</publisher><subject>Adult ; Alcohol Abuse ; Alcohol dependence ; Alcoholics ; Alcoholism ; Alcoholism - psychology ; Alcoholism - therapy ; Brain ; Care and treatment ; Clinical trials ; Cognition ; Cognitive ability ; Cognitive functioning ; Cognitive stimulation ; Cognitive Therapy - methods ; Computer & video games ; Cortex ; Drug addiction ; Dysfunction ; Educational software ; Executive Function ; Executives ; Feedback ; Female ; Flexibility ; Games ; Humans ; Intervention ; Male ; Medical Research ; Memory ; Middle Aged ; Mortality ; Motivation ; Neuropsychological assessment ; Neuropsychological Tests ; Neuropsychology ; Original Paper ; Patients ; Rehabilitation ; Substance abuse ; Substance abuse treatment ; Surveys ; Symptoms ; Technology ; Trials ; University students ; Withdrawal symptoms</subject><ispartof>Journal of medical Internet research, 2014-04, Vol.16 (4), p.e102</ispartof><rights>COPYRIGHT 2014 Journal of Medical Internet Research</rights><rights>2014. This work is licensed under http://creativecommons.org/licenses/by/2.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Pedro Gamito, Jorge Oliveira, Paulo Lopes, Rodrigo Brito, Diogo Morais, Diana Silva, Ana Silva, Sara Rebelo, Marta Bastos, Alberto Deus. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 17.04.2014. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c671t-9ac15e7ab226d3a6b0c4591ea2e70ed10ddd9be411c6f67cb763df475799bb133</citedby><cites>FETCH-LOGICAL-c671t-9ac15e7ab226d3a6b0c4591ea2e70ed10ddd9be411c6f67cb763df475799bb133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2512903677/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2512903677?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,12846,21381,21394,25753,27305,27924,27925,30999,33611,33612,33775,33906,33907,34135,37012,37013,43733,43892,44590,74221,74409,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24742381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gamito, Pedro</creatorcontrib><creatorcontrib>Oliveira, Jorge</creatorcontrib><creatorcontrib>Lopes, Paulo</creatorcontrib><creatorcontrib>Brito, Rodrigo</creatorcontrib><creatorcontrib>Morais, Diogo</creatorcontrib><creatorcontrib>Silva, Diana</creatorcontrib><creatorcontrib>Silva, Ana</creatorcontrib><creatorcontrib>Rebelo, Sara</creatorcontrib><creatorcontrib>Bastos, Marta</creatorcontrib><creatorcontrib>Deus, Alberto</creatorcontrib><title>Executive functioning in alcoholics following an mHealth cognitive stimulation program: randomized controlled trial</title><title>Journal of medical Internet research</title><addtitle>J Med Internet Res</addtitle><description>The consequences of alcohol dependence are severe and may range from physical disease to neuropsychological deficits in several cognitive domains. Alcohol abuse has also been related to brain dysfunction specifically in the prefrontal cortex. Conventional neuropsychological interventions (paper-and-pencil cognitive stimulation training) have a positive effect but are time-consuming, costly, and not motivating for patients.
Our goal was to test the cognitive effects of a novel approach to neuropsychological intervention, using mobile technology and serious games, on patients with alcohol dependence.
The trial design consisted of a two-arm study assessing the cognitive outcomes of neuropsychological intervention with mobile serious games (mHealth) versus control (treatment-as-usual with no neuropsychological intervention) in patients undergoing treatment for alcohol dependence syndrome. Sixty-eight patients were recruited from an alcohol-rehab clinic and randomly assigned to the mHealth (n=33) or control condition (n=35). The intervention on the experimental group consisted of a therapist-assisted cognitive stimulation therapy for 4 weeks on a 2-3 days/week basis.
Fourteen patients dropped out of the study. The results of the neuropsychological assessments with the remaining 54 patients showed an overall increase (P<.05) of general cognitive abilities, mental flexibility, psychomotor processing speed, and attentional ability in both experimental (n=26) and control groups (n=28). However, there was a more pronounced improvement (P=.01) specifically in frontal lobe functions from baseline (mean 13.89, SE 0.58) to follow-up (mean 15.50, SE 0.46) in the experimental group but not in the control group.
The overall increase in general cognitive function for both experimental and control groups supports the beneficial role of existing alcohol treatment protocols aimed at minimizing withdrawal symptoms, but the differential improvements observed in frontal lobe functioning supports the use of mobile serious games for neuropsychological stimulation to overcome executive dysfunction in patients with alcohol dependence. This trial was negative on two neuropsychological/cognitive tests, and positive on one.
ClinicalTrials.gov NCT01942954; http://www.clinicaltrials.gov/ct2/show/NCT01942954.</description><subject>Adult</subject><subject>Alcohol Abuse</subject><subject>Alcohol dependence</subject><subject>Alcoholics</subject><subject>Alcoholism</subject><subject>Alcoholism - psychology</subject><subject>Alcoholism - therapy</subject><subject>Brain</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cognitive functioning</subject><subject>Cognitive stimulation</subject><subject>Cognitive Therapy - methods</subject><subject>Computer & video games</subject><subject>Cortex</subject><subject>Drug addiction</subject><subject>Dysfunction</subject><subject>Educational software</subject><subject>Executive Function</subject><subject>Executives</subject><subject>Feedback</subject><subject>Female</subject><subject>Flexibility</subject><subject>Games</subject><subject>Humans</subject><subject>Intervention</subject><subject>Male</subject><subject>Medical Research</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Motivation</subject><subject>Neuropsychological assessment</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Rehabilitation</subject><subject>Substance abuse</subject><subject>Substance abuse treatment</subject><subject>Surveys</subject><subject>Symptoms</subject><subject>Technology</subject><subject>Trials</subject><subject>University students</subject><subject>Withdrawal symptoms</subject><issn>1438-8871</issn><issn>1439-4456</issn><issn>1438-8871</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><sourceid>F2A</sourceid><sourceid>ALSLI</sourceid><sourceid>CNYFK</sourceid><sourceid>M1O</sourceid><sourceid>PIMPY</sourceid><sourceid>BHHNA</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1v1DAQhiMEoh9w4A-gSFzoYRePndgxh0pVVehKFRyAs-XYTtYrx17spBR-Pc62lC6qkA8ejZ95x_NRFK8ALTFw-m4z2LjEHJMnxSFUpFk0DYOnD-yD4iilDUIYVRyeFwe4YhUmDRwW6eLGqGm016bsJq9GG7z1fWl9KZ0K6-CsSmUXnAs_Zr_05XBppBvXpQq9t7vANNphcnKOLbcx9FEO78sovQ6D_WV0Jv0Ys0Q2x2ile1E866RL5uXdfVx8-3Dx9fxycfX54-r87GqhKINxwaWC2jDZYkw1kbRFqqo5GIkNQ0YD0lrz1lQAinaUqZZRoruK1YzztgVCjovVra4OciO20Q4y_hRBWrFzhNgLGUernBGMVBJDi-uGNxUgypHuWlYjLnlOAjhrnd5qbad2MFqZXJJ0e6L7L96uRR-uRYWAM8azwNs7gRi-TyaNYrBJGeekN2FKAijHuCFkl-vNP-gmTNHnVglcA-aIUMb-RwGlNeRWAfylepnLtL4L-XdqTi3OGOWkpjlhppaPUPloM9g8PtPZ7N8LONkLmEdsbsZeTimJ1ZdPj7IqhpSi6e67BkjM-yvm_RXz_mb29cM235N_Fpb8Bhuj6s0</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Gamito, Pedro</creator><creator>Oliveira, Jorge</creator><creator>Lopes, Paulo</creator><creator>Brito, Rodrigo</creator><creator>Morais, Diogo</creator><creator>Silva, Diana</creator><creator>Silva, Ana</creator><creator>Rebelo, Sara</creator><creator>Bastos, Marta</creator><creator>Deus, Alberto</creator><general>Journal of Medical Internet Research</general><general>Gunther Eysenbach MD MPH, Associate Professor</general><general>JMIR Publications Inc</general><general>JMIR Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>7QJ</scope><scope>8BP</scope><scope>E3H</scope><scope>F2A</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CNYFK</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>KB0</scope><scope>M0S</scope><scope>M1O</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U3</scope><scope>BHHNA</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140401</creationdate><title>Executive functioning in alcoholics following an mHealth cognitive stimulation program: randomized controlled trial</title><author>Gamito, Pedro ; Oliveira, Jorge ; Lopes, Paulo ; Brito, Rodrigo ; Morais, Diogo ; Silva, Diana ; Silva, Ana ; Rebelo, Sara ; Bastos, Marta ; Deus, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c671t-9ac15e7ab226d3a6b0c4591ea2e70ed10ddd9be411c6f67cb763df475799bb133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Alcohol Abuse</topic><topic>Alcohol dependence</topic><topic>Alcoholics</topic><topic>Alcoholism</topic><topic>Alcoholism - psychology</topic><topic>Alcoholism - therapy</topic><topic>Brain</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cognitive functioning</topic><topic>Cognitive stimulation</topic><topic>Cognitive Therapy - methods</topic><topic>Computer & video games</topic><topic>Cortex</topic><topic>Drug addiction</topic><topic>Dysfunction</topic><topic>Educational software</topic><topic>Executive Function</topic><topic>Executives</topic><topic>Feedback</topic><topic>Female</topic><topic>Flexibility</topic><topic>Games</topic><topic>Humans</topic><topic>Intervention</topic><topic>Male</topic><topic>Medical Research</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Motivation</topic><topic>Neuropsychological assessment</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Rehabilitation</topic><topic>Substance abuse</topic><topic>Substance abuse treatment</topic><topic>Surveys</topic><topic>Symptoms</topic><topic>Technology</topic><topic>Trials</topic><topic>University students</topic><topic>Withdrawal symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gamito, Pedro</creatorcontrib><creatorcontrib>Oliveira, Jorge</creatorcontrib><creatorcontrib>Lopes, Paulo</creatorcontrib><creatorcontrib>Brito, Rodrigo</creatorcontrib><creatorcontrib>Morais, Diogo</creatorcontrib><creatorcontrib>Silva, Diana</creatorcontrib><creatorcontrib>Silva, Ana</creatorcontrib><creatorcontrib>Rebelo, Sara</creatorcontrib><creatorcontrib>Bastos, Marta</creatorcontrib><creatorcontrib>Deus, Alberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Library & Information Sciences Abstracts (LISA) - 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Alcohol abuse has also been related to brain dysfunction specifically in the prefrontal cortex. Conventional neuropsychological interventions (paper-and-pencil cognitive stimulation training) have a positive effect but are time-consuming, costly, and not motivating for patients.
Our goal was to test the cognitive effects of a novel approach to neuropsychological intervention, using mobile technology and serious games, on patients with alcohol dependence.
The trial design consisted of a two-arm study assessing the cognitive outcomes of neuropsychological intervention with mobile serious games (mHealth) versus control (treatment-as-usual with no neuropsychological intervention) in patients undergoing treatment for alcohol dependence syndrome. Sixty-eight patients were recruited from an alcohol-rehab clinic and randomly assigned to the mHealth (n=33) or control condition (n=35). The intervention on the experimental group consisted of a therapist-assisted cognitive stimulation therapy for 4 weeks on a 2-3 days/week basis.
Fourteen patients dropped out of the study. The results of the neuropsychological assessments with the remaining 54 patients showed an overall increase (P<.05) of general cognitive abilities, mental flexibility, psychomotor processing speed, and attentional ability in both experimental (n=26) and control groups (n=28). However, there was a more pronounced improvement (P=.01) specifically in frontal lobe functions from baseline (mean 13.89, SE 0.58) to follow-up (mean 15.50, SE 0.46) in the experimental group but not in the control group.
The overall increase in general cognitive function for both experimental and control groups supports the beneficial role of existing alcohol treatment protocols aimed at minimizing withdrawal symptoms, but the differential improvements observed in frontal lobe functioning supports the use of mobile serious games for neuropsychological stimulation to overcome executive dysfunction in patients with alcohol dependence. This trial was negative on two neuropsychological/cognitive tests, and positive on one.
ClinicalTrials.gov NCT01942954; http://www.clinicaltrials.gov/ct2/show/NCT01942954.</abstract><cop>Canada</cop><pub>Journal of Medical Internet Research</pub><pmid>24742381</pmid><doi>10.2196/jmir.2923</doi><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Adult Alcohol Abuse Alcohol dependence Alcoholics Alcoholism Alcoholism - psychology Alcoholism - therapy Brain Care and treatment Clinical trials Cognition Cognitive ability Cognitive functioning Cognitive stimulation Cognitive Therapy - methods Computer & video games Cortex Drug addiction Dysfunction Educational software Executive Function Executives Feedback Female Flexibility Games Humans Intervention Male Medical Research Memory Middle Aged Mortality Motivation Neuropsychological assessment Neuropsychological Tests Neuropsychology Original Paper Patients Rehabilitation Substance abuse Substance abuse treatment Surveys Symptoms Technology Trials University students Withdrawal symptoms |
| title | Executive functioning in alcoholics following an mHealth cognitive stimulation program: randomized controlled trial |
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