Local anesthetics systemic toxicity in children: analysis of the French pharmacovigilance database

To characterize clinical profile of pediatric local anesthetic (LA) systemic toxicity (LAST) and to identify determinants of life-threatening outcomes. Spontaneous reports notified to the French Pharmacovigilance Network were retrieved and followed by a case-by-case review, according to the followin...

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Bibliographic Details
Published in:BMC pediatrics 2023-06, Vol.23 (1), p.321-321, Article 321
Main Authors: Schweitzer-Chaput, Arnaud, Callot, Delphine, Bouazza, Naim, Lesage, Fabrice, Oualha, Mehdi, Paret, Nathalie, Boyer-Gervoise, Marie, Treluyer, Jean-Marc, Chouchana, Laurent
Format: Article
Language:English
Subjects:
Adolescent
Adverse and side effects
Adverse drug reaction
Anesthetics, Local - adverse effects
Benzodiazepines
Bone surgery
Cardiopulmonary resuscitation
Child
CPR
Drug dosages
Drugs
Epidural
Health aspects
Hospitalization
Humans
Infant
Infant, Newborn
Lidocaine
Lidocaine, Prilocaine Drug Combination
Lipids
Local anesthesia
Local anesthetics
Orthopedics
Pediatric
Pediatric anesthesia
Pediatrics
Pharmacovigilance
Retrospective Studies
Ropivacaine
Systemic toxicity
Toxicity
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Summary:To characterize clinical profile of pediatric local anesthetic (LA) systemic toxicity (LAST) and to identify determinants of life-threatening outcomes. Spontaneous reports notified to the French Pharmacovigilance Network were retrieved and followed by a case-by-case review, according to the following criteria: LA as suspected drug, age 
ISSN:1471-2431
1471-2431
DOI:10.1186/s12887-023-04126-7