Maternal Inflammation, Fetal Brain Implications and Suggested Neuroprotection: A Summary of 10 Years of Research in Animal Models

A growing body of evidence implies that maternal inflammation during pregnancy is associated with increased risk of neurodevelopmental disorders in the offspring. The pathophysiological mechanisms by which maternal inflammation evokes fetal brain injury and contributes to long-term adverse neurologi...

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Bibliographic Details
Published in:Rambam Maimonides medical journal 2017-04, Vol.8 (2), p.e0028
Main Authors: Ginsberg, Yuval, Khatib, Nizar, Weiner, Zeev, Beloosesky, Ron
Format: Article
Language:English
Subjects:
Fetal brain injury
magnesium sulfate
maternal inflammation
N-acetyl cysteine neuroprotection
Special Issue on Gynecology, Fertility, and Obstetrics
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Summary:A growing body of evidence implies that maternal inflammation during pregnancy is associated with increased risk of neurodevelopmental disorders in the offspring. The pathophysiological mechanisms by which maternal inflammation evokes fetal brain injury and contributes to long-term adverse neurological outcomes are not completely understood. In this review, we summarize 10 years of our research experience on maternal inflammation and the implications upon the fetal/offspring brain. We review our findings regarding the underlying mechanisms that connects maternal inflammation and fetal brain injuries (e.g. cytokines, oxidative stress); we discuss our imaging, pathological and behavioral test results which support brain damage following maternal inflammation; and finally we describe some of the therapeutic strategies which might prevent the damage.
ISSN:2076-9172
2076-9172
DOI:10.5041/RMMJ.10305