Protocatechuic Acid and Syringin from Saussurea neoserrata Nakai Attenuate Prostaglandin Production in Human Keratinocytes Exposed to Airborne Particulate Matter

• Published in: Current issues in molecular biology 2023-07, Vol.45 (7), p.5950-5966
• Main Authors: Jeong, Myeongguk, Ju, Yeongdon, Kwon, Hyeokjin, Kim, Yeeun, Hyun, Kyung-Yae, Choi, Go-Eun
• Format: Article
• Language: English
• Subjects: antioxidant; particulate matter; preparative liquid chromatography; protocatechuic acid; Saussurea neoserrata Nakai; syringin
• ISSN: 1467-3045; 1467-3037; 1467-3045
• DOI: 10.3390/cimb45070376

Nakai offers a reliable and efficient source of antioxidants that can help alleviate adverse skin reactions triggered by air pollutants. Air pollutants, such as particulate matter (PM), have the ability to infiltrate the skin and contribute to the higher occurrence of cardiovascular, cerebrovascular, and respiratory ailments. Individuals with compromised skin barriers are particularly susceptible to the impact of PM since it can be absorbed more readily through the skin. This study investigated the impact of protocatechuic acid and syringin, obtained from the n-BuOH extract of Nakai, on the release of PGE and PGD induced by PM . Additionally, it examined the gene expression of the synthesis of PGE and PGD in human keratinocytes. The findings of this research highlight the potential of utilizing safe and efficient plant-derived antioxidants in dermatological and cosmetic applications to mitigate the negative skin reactions caused by exposure to air pollution.