Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replicating selected results from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012 were selec...

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Bibliographic Details
Published in:eLife 2015-07, Vol.4, p.e04796-163
Main Authors: Fiering, Steven, Ang, Lay-Hong, Lacoste, Judith, Smith, Tim D, Griner, Erin
Format: Article
Language:English
Subjects:
Animals
biochemical remodeling
Biophysics and Structural Biology
Cancer
Caveolin
Caveolin 1 - metabolism
Caveolin-1
Cell Biology
Disease Models, Animal
Experiments
Extracellular matrix
Fibroblasts
Melanoma
Metastases
Metastasis
methodology
Neoplasm Metastasis - pathology
Neoplasms - pathology
Registered Report
Reproducibility
Reproducibility Project: Cancer Biology
Software
tumor microenvironment
Tumors
Xenografts
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Summary:The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replicating selected results from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012 were selected on the basis of citations and Altimetric scores (Errington et al., 2014). This Registered report describes the proposed replication plan of key experiments from 'Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis' by Goetz and colleagues, published in Cell in 2011 (Goetz et al., 2011). The key experiments being replicated are those reported in Figures 7C (a-d), Supplemental Figure S2A, and Supplemental Figure S7C (a-c) (Goetz et al., 2011). In these experiments, which are a subset of all the experiments reported in the original publication, Goetz and colleagues show in a subcutaneous xenograft model that stromal caveolin-1 remodels the intratumoral microenvironment, which is correlated with increased metastasis formation. The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange and the results of the replications will be published in eLife.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.04796