A flexible neural implant with ultrathin substrate for low-invasive brain–computer interface applications

Implantable brain–computer interface (BCI) devices are an effective tool to decipher fundamental brain mechanisms and treat neural diseases. However, traditional neural implants with rigid or bulky cross-sections cause trauma and decrease the quality of the neuronal signal. Here, we propose a MEMS-f...

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Bibliographic Details
Published in:Microsystems & nanoengineering 2022-12, Vol.8 (1), p.133-133, Article 133
Main Authors: Guo, Zhejun, Wang, Fang, Wang, Longchun, Tu, Kejun, Jiang, Chunpeng, Xi, Ye, Hong, Wen, Xu, Qingda, Wang, Xiaolin, Yang, Bin, Sun, Bomin, Lin, Zude, Liu, Jingquan
Format: Article
Language:English
Subjects:
639/925/350
639/925/927/511
Cross-sections
Electrophysiological recording
Engineering
Firing pattern
Human-computer interface
Implantation
In vivo methods and tests
Microelectromechanical systems
Neural prostheses
Polyethylene glycol
Signal quality
Storage capacity
Thin films
Transplants & implants
Trauma
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Summary:Implantable brain–computer interface (BCI) devices are an effective tool to decipher fundamental brain mechanisms and treat neural diseases. However, traditional neural implants with rigid or bulky cross-sections cause trauma and decrease the quality of the neuronal signal. Here, we propose a MEMS-fabricated flexible interface device for BCI applications. The microdevice with a thin film substrate can be readily reduced to submicron scale for low-invasive implantation. An elaborate silicon shuttle with an improved structure is designed to reliably implant the flexible device into brain tissue. The flexible substrate is temporarily bonded to the silicon shuttle by polyethylene glycol. On the flexible substrate, eight electrodes with different diameters are distributed evenly for local field potential and neural spike recording, both of which are modified by Pt-black to enhance the charge storage capacity and reduce the impedance. The mechanical and electrochemical characteristics of this interface were investigated in vitro. In vivo, the small cross-section of the device promises reduced trauma, and the neuronal signals can still be recorded one month after implantation, demonstrating the promise of this kind of flexible BCI device as a low-invasive tool for brain–computer communication.
ISSN:2055-7434
2096-1030
2055-7434
DOI:10.1038/s41378-022-00464-1