The progress and challenges of circRNA for diabetic foot ulcers: A mini-review

Since the Human Genome Project was successfully completed, humanity has entered a post-genome era, and the second-generation sequencing technology has gradually progressed and become more accurate. Meanwhile, circRNAs plays a crucial role in the regulation of diseases and potential clinical applicat...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2022-11, Vol.13, p.1019935
Main Authors: Li, Deer, Guo, Jiaxing, Ni, Xiyu, Sun, Guanwen, Bao, Huhe
Format: Article
Language:English
Subjects:
circRNAs
Diabetes Mellitus
Diabetic Foot
diabetic foot ulcers
diagnostic markers
differential expression
Endocrinology
Humans
RNA, Circular - genetics
therapeutic targets
Wound Healing - genetics
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Summary:Since the Human Genome Project was successfully completed, humanity has entered a post-genome era, and the second-generation sequencing technology has gradually progressed and become more accurate. Meanwhile, circRNAs plays a crucial role in the regulation of diseases and potential clinical applications has gradually attracted the attention of physicians. However, the mechanisms of circRNAs regulation at the cellular and molecular level of diabetic foot ulcer (DFU) is still not well-understood. With the deepening of research, there have been many recent studies conducted to explore the effect of circRNAs on DFU. In this mini-review, we discuss the potential role of circRNAs as therapeutic targets and diagnostic markers for DFU in order to gain a better understanding of the molecular mechanisms that underlie the development of DFU and to establish a theoretical basis for accurate treatment and effective prevention.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.1019935