Multidisciplinary and Tailored Treatment of Locally Advanced Breast Cancer in Progression during Neoadjuvant Chemotherapy: Case Report

Locally advanced breast cancer (LABC) is a complex disease that requires a multidisciplinary approach. Neoadjuvant chemotherapy (NAC) is usually performed in order to achieve loco-regional radical resection; although its importance in the multidisciplinary approach to LABC is well recognized, a smal...

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Bibliographic Details
Published in:Current oncology (Toronto) 2024-05, Vol.31 (5), p.2856-2866
Main Authors: Cuniolo, Letizia, Gipponi, Marco, Murelli, Federica, Depaoli, Francesca, Cornacchia, Chiara, Franchelli, Simonetta, Pesce, Marianna, Ronda, Elena, Picardi, Stefano, Diaz, Raquel, Poggio, Francesca, Friedman, Daniele, De Cian, Franco, Fregatti, Piero
Format: Article
Language:English
Subjects:
Adjuvant treatment
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Cancer
Care and treatment
Development and progression
Disease Progression
Female
Humans
Ixabepilone
locally advanced breast cancer (LABC)
Metronidazole
Middle Aged
Neoadjuvant Therapy - methods
progressive disease (PD)
Radiotherapy
salvage treatment (ST)
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Summary:Locally advanced breast cancer (LABC) is a complex disease that requires a multidisciplinary approach. Neoadjuvant chemotherapy (NAC) is usually performed in order to achieve loco-regional radical resection; although its importance in the multidisciplinary approach to LABC is well recognized, a small number of patients show Progressive Disease (PD). No standard salvage treatment (ST) has been defined and different strategies can be adopted, such as second-line systemic therapies, radiation therapy, and surgery. Herein, a case of LABC in PD during NAC is reported with a literature review, with the aim of highlighting the importance of a tailored multidisciplinary treatment for each patient.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol31050217