The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have...

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Bibliographic Details
Published in:Frontiers in immunology 2019-10, Vol.10, p.2388-2388
Main Authors: Urban-Wojciuk, Zuzanna, Khan, Mohd M, Oyler, Benjamin L, Fåhraeus, Robin, Marek-Trzonkowska, Natalia, Nita-Lazar, Aleksandra, Hupp, Ted R, Goodlett, David R
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - metabolism
Animals
anti-cancer immunity
Gene Expression Regulation, Neoplastic
Humans
Immunity
immuno-oncology
Immunology
immunotherapy
Ligands
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Neoplasms - therapy
Organ Specificity - genetics
Organ Specificity - immunology
Protein Binding
toll-like receptors
Toll-Like Receptors - agonists
Toll-Like Receptors - genetics
Toll-Like Receptors - metabolism
tumor rejection
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Summary:In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have long been used as adjuvants for traditional vaccines and it seems they may also play a role enhancing efficiency of tumor immunotherapy. The aim of this perspective is to discuss the effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role of TLRs in anti-cancer immunity and tumor rejection.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.02388