Association between the ROX index and mortality in patients with acute hypoxemic respiratory failure: a retrospective cohort study

• Published in: Respiratory research 2024-03, Vol.25 (1), p.143-143, Article 143
• Main Authors: Liu, Kai, Ma, Xin-Yi, Xiao, Hua, Gu, Wan-Jie, Lyu, Jun, Yin, Hai-Yan
• Format: Article
• Language: English
• Subjects: Acute hypoxemic respiratory failure; Biological markers; Care and treatment; Cerebrovascular disease; Creatinine; Diagnosis; Evaluation; Extracorporeal membrane oxygenation; Gender; Health risks; Hospitalization; Hospitals; Hypotheses; Liver diseases; MIMIC-IV; Missing data; Mortality; Mortality risk; Oxygen saturation; Patients; Potassium; Prognosis; Respiratory failure; Respiratory insufficiency; Risk; ROX index; Spline functions; Statistical analysis; Structured Query Language-SQL; Survival analysis; Variables; Ventilators
• ISSN: 1465-993X; 1465-9921; 1465-993X; 1465-9921
• DOI: 10.1186/s12931-024-02771-9

Although ROX index is frequently used to assess the efficacy of high-flow nasal cannula treatment in acute hypoxemic respiratory failure (AHRF) patients, the relationship between the ROX index and the mortality remains unclear. Therefore, a retrospective cohort study was conducted to evaluate the ability of the ROX index to predict mortality risk in patients with AHRF. Patients diagnosed with AHRF were extracted from the MIMIC-IV database and divided into four groups based on the ROX index quartiles. The primary outcome was 28-day mortality, while in-hospital mortality and follow-up mortality were secondary outcomes. To investigate the association between ROX index and mortality in AHRF patients, restricted cubic spline curve and COX proportional risk regression were utilized. A non-linear association (L-shaped) has been observed between the ROX index and mortality rate. When the ROX index is below 8.28, there is a notable decline in the 28-day mortality risk of patients as the ROX index increases (HR per SD, 0.858 [95%CI 0.794-0.928] P