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Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression
Background Excipients with improved functionality have continued to be developed by the particle engineering strategy of co-processing. The aim of this study was to evaluate the compaction and tableting properties of composite particles of microcrystalline cellulose (MCC) and crospovidone (CPV) engi...
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| Published in: | Future journal of pharmaceutical sciences 2020-07, Vol.6 (1), p.35-9, Article 35 |
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| cites | cdi_FETCH-LOGICAL-c426t-e8f2c687835943c966092932e6c81d7d5f3b6a2b145ae1b44ce3083f98d687683 |
| container_end_page | 9 |
| container_issue | 1 |
| container_start_page | 35 |
| container_title | Future journal of pharmaceutical sciences |
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| creator | Haruna, Fatima Apeji, Yonni Eshovo Oparaeche, Chinyere Oyi, Avosuahi Rukayat Gamlen, Michael |
| description | Background
Excipients with improved functionality have continued to be developed by the particle engineering strategy of co-processing. The aim of this study was to evaluate the compaction and tableting properties of composite particles of microcrystalline cellulose (MCC) and crospovidone (CPV) engineered by co-processing.
Results
Heckel analysis of the compaction behavior revealed a decrease in plasticity of co-processed excipient (CPE) when compared to MCC due to an increase in Heckel yield pressure from 144 to 172 MPa. The compressibility-tabletability-compactibility (CTC) profile revealed a decrease in individual parameters for CPE when compared to MCC. CPE was found to be more sensitive to the lubricant effect of sodium stearyl fumarate (SSF) when compared to MCC and less sensitive to magnesium stearate (MST) when compared to MCC. A higher dilution potential was obtained for MCC (60%) compared to 44% for CPE when metronidazole was used as model drug. Tableting properties revealed that metronidazole tablets generated with CPE by direct compression disintegrated within 15 min and gave a rapid drug release when compared to MCC as a direct compression (DC) excipient.
Conclusion
The compaction and tableting properties of CPE were characterized and yielded tablets with better disintegration and drug release profile when compared to MCC. This study, therefore, confirms the suitability of co-processing as a proven strategy in engineering the performance of excipients. |
| doi_str_mv | 10.1186/s43094-020-00055-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_737c34ad4ccd4c5992be962ac9ede648</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_737c34ad4ccd4c5992be962ac9ede648</doaj_id><sourcerecordid>2729533080</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-e8f2c687835943c966092932e6c81d7d5f3b6a2b145ae1b44ce3083f98d687683</originalsourceid><addsrcrecordid>eNp9UctqHDEQHEwMMY5_ICeBzxPrNRrpGBa_wJBLfBYaqWfRMjuaSFqDv8E_nd4d4_iUg5CorqpudTXNd0Z_MKbVTZGCGtlSTltKade15qy54ILJtued-PLp_bW5KmWHJKal5IpeNG-btF-crzHNxM2BVDdMUOO8JUtOC-QaoZA0Eo-0VGIFsjgE_bTC--hz8vm1VDdNcQbiYZoOUypwcsNiWdJLDAlLMG-RARkCGVMmIWbw9WScoRQc4FtzPrqpwNX7fdk8393-3jy0T7_uHzc_n1qPM9cW9Mi90r0WnZHCG6Wo4UZwUF6z0IduFINyfGCyc8AGKT0IqsVodECV0uKyeVx9Q3I7u-S4d_nVJhftCUh5a9__aHvReyFdkN7j6YzhAxjFnTcQQMmj1_Xqhev6c4BS7S4d8ozjW95z0wlsTZHFV9ZxISXD-NGVUXvM0K4ZWszQnjK0BkViFRUkz1vI_6z_o_oLygOh-g</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2729533080</pqid></control><display><type>article</type><title>Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>Springer Nature - SpringerLink Journals - Fully Open Access </source><creator>Haruna, Fatima ; Apeji, Yonni Eshovo ; Oparaeche, Chinyere ; Oyi, Avosuahi Rukayat ; Gamlen, Michael</creator><creatorcontrib>Haruna, Fatima ; Apeji, Yonni Eshovo ; Oparaeche, Chinyere ; Oyi, Avosuahi Rukayat ; Gamlen, Michael</creatorcontrib><description>Background
Excipients with improved functionality have continued to be developed by the particle engineering strategy of co-processing. The aim of this study was to evaluate the compaction and tableting properties of composite particles of microcrystalline cellulose (MCC) and crospovidone (CPV) engineered by co-processing.
Results
Heckel analysis of the compaction behavior revealed a decrease in plasticity of co-processed excipient (CPE) when compared to MCC due to an increase in Heckel yield pressure from 144 to 172 MPa. The compressibility-tabletability-compactibility (CTC) profile revealed a decrease in individual parameters for CPE when compared to MCC. CPE was found to be more sensitive to the lubricant effect of sodium stearyl fumarate (SSF) when compared to MCC and less sensitive to magnesium stearate (MST) when compared to MCC. A higher dilution potential was obtained for MCC (60%) compared to 44% for CPE when metronidazole was used as model drug. Tableting properties revealed that metronidazole tablets generated with CPE by direct compression disintegrated within 15 min and gave a rapid drug release when compared to MCC as a direct compression (DC) excipient.
Conclusion
The compaction and tableting properties of CPE were characterized and yielded tablets with better disintegration and drug release profile when compared to MCC. This study, therefore, confirms the suitability of co-processing as a proven strategy in engineering the performance of excipients.</description><identifier>ISSN: 2314-7253</identifier><identifier>ISSN: 2314-7245</identifier><identifier>EISSN: 2314-7253</identifier><identifier>DOI: 10.1186/s43094-020-00055-9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cellulose ; Compaction studies ; Crospovidone ; Deformation ; Density ; Medicine ; Medicine & Public Health ; Microcrystalline cellulose ; Particle engineering ; Particle size ; Pharmaceutical sciences ; Physical properties ; Tablet ; Tensile strength</subject><ispartof>Future journal of pharmaceutical sciences, 2020-07, Vol.6 (1), p.35-9, Article 35</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-e8f2c687835943c966092932e6c81d7d5f3b6a2b145ae1b44ce3083f98d687683</citedby><cites>FETCH-LOGICAL-c426t-e8f2c687835943c966092932e6c81d7d5f3b6a2b145ae1b44ce3083f98d687683</cites><orcidid>0000-0002-3116-7570</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2729533080/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2729533080?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590,75126</link.rule.ids></links><search><creatorcontrib>Haruna, Fatima</creatorcontrib><creatorcontrib>Apeji, Yonni Eshovo</creatorcontrib><creatorcontrib>Oparaeche, Chinyere</creatorcontrib><creatorcontrib>Oyi, Avosuahi Rukayat</creatorcontrib><creatorcontrib>Gamlen, Michael</creatorcontrib><title>Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression</title><title>Future journal of pharmaceutical sciences</title><addtitle>Futur J Pharm Sci</addtitle><description>Background
Excipients with improved functionality have continued to be developed by the particle engineering strategy of co-processing. The aim of this study was to evaluate the compaction and tableting properties of composite particles of microcrystalline cellulose (MCC) and crospovidone (CPV) engineered by co-processing.
Results
Heckel analysis of the compaction behavior revealed a decrease in plasticity of co-processed excipient (CPE) when compared to MCC due to an increase in Heckel yield pressure from 144 to 172 MPa. The compressibility-tabletability-compactibility (CTC) profile revealed a decrease in individual parameters for CPE when compared to MCC. CPE was found to be more sensitive to the lubricant effect of sodium stearyl fumarate (SSF) when compared to MCC and less sensitive to magnesium stearate (MST) when compared to MCC. A higher dilution potential was obtained for MCC (60%) compared to 44% for CPE when metronidazole was used as model drug. Tableting properties revealed that metronidazole tablets generated with CPE by direct compression disintegrated within 15 min and gave a rapid drug release when compared to MCC as a direct compression (DC) excipient.
Conclusion
The compaction and tableting properties of CPE were characterized and yielded tablets with better disintegration and drug release profile when compared to MCC. This study, therefore, confirms the suitability of co-processing as a proven strategy in engineering the performance of excipients.</description><subject>Cellulose</subject><subject>Compaction studies</subject><subject>Crospovidone</subject><subject>Deformation</subject><subject>Density</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microcrystalline cellulose</subject><subject>Particle engineering</subject><subject>Particle size</subject><subject>Pharmaceutical sciences</subject><subject>Physical properties</subject><subject>Tablet</subject><subject>Tensile strength</subject><issn>2314-7253</issn><issn>2314-7245</issn><issn>2314-7253</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9UctqHDEQHEwMMY5_ICeBzxPrNRrpGBa_wJBLfBYaqWfRMjuaSFqDv8E_nd4d4_iUg5CorqpudTXNd0Z_MKbVTZGCGtlSTltKade15qy54ILJtued-PLp_bW5KmWHJKal5IpeNG-btF-crzHNxM2BVDdMUOO8JUtOC-QaoZA0Eo-0VGIFsjgE_bTC--hz8vm1VDdNcQbiYZoOUypwcsNiWdJLDAlLMG-RARkCGVMmIWbw9WScoRQc4FtzPrqpwNX7fdk8393-3jy0T7_uHzc_n1qPM9cW9Mi90r0WnZHCG6Wo4UZwUF6z0IduFINyfGCyc8AGKT0IqsVodECV0uKyeVx9Q3I7u-S4d_nVJhftCUh5a9__aHvReyFdkN7j6YzhAxjFnTcQQMmj1_Xqhev6c4BS7S4d8ozjW95z0wlsTZHFV9ZxISXD-NGVUXvM0K4ZWszQnjK0BkViFRUkz1vI_6z_o_oLygOh-g</recordid><startdate>20200717</startdate><enddate>20200717</enddate><creator>Haruna, Fatima</creator><creator>Apeji, Yonni Eshovo</creator><creator>Oparaeche, Chinyere</creator><creator>Oyi, Avosuahi Rukayat</creator><creator>Gamlen, Michael</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3116-7570</orcidid></search><sort><creationdate>20200717</creationdate><title>Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression</title><author>Haruna, Fatima ; Apeji, Yonni Eshovo ; Oparaeche, Chinyere ; Oyi, Avosuahi Rukayat ; Gamlen, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-e8f2c687835943c966092932e6c81d7d5f3b6a2b145ae1b44ce3083f98d687683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cellulose</topic><topic>Compaction studies</topic><topic>Crospovidone</topic><topic>Deformation</topic><topic>Density</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microcrystalline cellulose</topic><topic>Particle engineering</topic><topic>Particle size</topic><topic>Pharmaceutical sciences</topic><topic>Physical properties</topic><topic>Tablet</topic><topic>Tensile strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haruna, Fatima</creatorcontrib><creatorcontrib>Apeji, Yonni Eshovo</creatorcontrib><creatorcontrib>Oparaeche, Chinyere</creatorcontrib><creatorcontrib>Oyi, Avosuahi Rukayat</creatorcontrib><creatorcontrib>Gamlen, Michael</creatorcontrib><collection>Springer Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Future journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haruna, Fatima</au><au>Apeji, Yonni Eshovo</au><au>Oparaeche, Chinyere</au><au>Oyi, Avosuahi Rukayat</au><au>Gamlen, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression</atitle><jtitle>Future journal of pharmaceutical sciences</jtitle><stitle>Futur J Pharm Sci</stitle><date>2020-07-17</date><risdate>2020</risdate><volume>6</volume><issue>1</issue><spage>35</spage><epage>9</epage><pages>35-9</pages><artnum>35</artnum><issn>2314-7253</issn><issn>2314-7245</issn><eissn>2314-7253</eissn><abstract>Background
Excipients with improved functionality have continued to be developed by the particle engineering strategy of co-processing. The aim of this study was to evaluate the compaction and tableting properties of composite particles of microcrystalline cellulose (MCC) and crospovidone (CPV) engineered by co-processing.
Results
Heckel analysis of the compaction behavior revealed a decrease in plasticity of co-processed excipient (CPE) when compared to MCC due to an increase in Heckel yield pressure from 144 to 172 MPa. The compressibility-tabletability-compactibility (CTC) profile revealed a decrease in individual parameters for CPE when compared to MCC. CPE was found to be more sensitive to the lubricant effect of sodium stearyl fumarate (SSF) when compared to MCC and less sensitive to magnesium stearate (MST) when compared to MCC. A higher dilution potential was obtained for MCC (60%) compared to 44% for CPE when metronidazole was used as model drug. Tableting properties revealed that metronidazole tablets generated with CPE by direct compression disintegrated within 15 min and gave a rapid drug release when compared to MCC as a direct compression (DC) excipient.
Conclusion
The compaction and tableting properties of CPE were characterized and yielded tablets with better disintegration and drug release profile when compared to MCC. This study, therefore, confirms the suitability of co-processing as a proven strategy in engineering the performance of excipients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43094-020-00055-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3116-7570</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cellulose Compaction studies Crospovidone Deformation Density Medicine Medicine & Public Health Microcrystalline cellulose Particle engineering Particle size Pharmaceutical sciences Physical properties Tablet Tensile strength |
| title | Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression |
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