Defining triple‐negative breast cancer with neuroendocrine differentiation (TNBC‐NED)

Primary breast neuroendocrine (NE) neoplasms are uncommon, and definitions harbor controversy. We retrospectively collected 73 triple‐negative breast cancers (TNBC) and evaluated NE biomarker expression along with p53 aberrant staining (which correlates with TP53 gene mutation) and Rb protein loss b...

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Bibliographic Details
Published in:The journal of pathology. Clinical research 2023-07, Vol.9 (4), p.313-321
Main Authors: Hacking, Sean M, Yakirevich, Evgeny, Wang, Yihong
Format: Article
Language:English
Subjects:
Biomarkers
breast
Breast cancer
Breast carcinoma
carcinoma
Cell division
Cloning
Cytoplasm
Estrogens
Gene expression
Immunohistochemistry
Insulinoma
Laboratories
Morphology
Mutation
neuroendocrine
Neuroendocrine tumors
Original
p53 Protein
Point mutation
Protein expression
Proteins
RB1
Retinoblastoma protein
Review boards
Statistical analysis
Synaptophysin
TNBC‐NED
TP53
Transcriptomics
Tumors
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Summary:Primary breast neuroendocrine (NE) neoplasms are uncommon, and definitions harbor controversy. We retrospectively collected 73 triple‐negative breast cancers (TNBC) and evaluated NE biomarker expression along with p53 aberrant staining (which correlates with TP53 gene mutation) and Rb protein loss by immunohistochemistry. In the study cohort, we found 11 (15%) cases of TNBC with neuroendocrine differentiation (TNBC‐NED) showing positivity for one or more NE markers (synaptophysin/chromogranin/insulinoma‐associated protein 1 [INSM1]). We also identified one separate small cell neuroendocrine carcinoma. Histologic types for these 11 TNBC‐NED cases were as follows: 8 invasive ductal carcinoma (IDC) not otherwise specified (NOS), 2 IDC with apocrine features, 1 IDC with solid papillary features. INSM1 had the highest positivity and was seen in all 11 carcinomas. Seven (64%) cases showed p53 aberrant staining, 6 (55%) had Rb protein loss, while 6 (55%) had p53/Rb co‐aberrant staining/protein loss. TNBC‐NED was associated with Rb protein loss (p 
ISSN:2056-4538
2056-4538
DOI:10.1002/cjp2.318