A ciliated adenocarcinoma of the lung mimicking lung abscess and pneumonia

This case report describes a 78‐year‐old man initially treated for pneumonia and lung abscess who was resistant to antimicrobial treatment and was eventually diagnosed with ciliated adenocarcinoma. Ciliated adenocarcinoma, a rare non‐terminal respiratory unit (TRU)‐type lung adenocarcinoma, presents...

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Bibliographic Details
Published in:Respirology case reports 2024-06, Vol.12 (6), p.e01407-n/a
Main Authors: Fujimoto, Naoki, Fujita, Kohei, Ishida, Ayami, Moriyoshi, Koki, Tanizawa, Kiminobu
Format: Article
Language:English
Subjects:
Abscesses
Antigens
Bronchoscopy
Case Report
Case Reports
ciliated adenocarcinoma
Infections
lung abscess
lung adenocarcinoma
Lung cancer
Morphology
non‐small cell lung cancer
Pneumonia
Thyroid gland
Tomography
Transcription factors
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Summary:This case report describes a 78‐year‐old man initially treated for pneumonia and lung abscess who was resistant to antimicrobial treatment and was eventually diagnosed with ciliated adenocarcinoma. Ciliated adenocarcinoma, a rare non‐terminal respiratory unit (TRU)‐type lung adenocarcinoma, presents a unique diagnostic challenge because of its similarity to pneumonia and lung abscesses. Morphologically, the ciliated adenocarcinoma in this case appeared to be a non‐TRU type adenocarcinoma, with partial mucous epithelium, no visible extracellular mucus, thyroid transcription factor (TTF)‐1 negativity, and mucin (MUC) 5AC positivity on immunostaining. The patient was considered to have ciliated adenocarcinoma based on the fact that the mucous epithelium was partial and extracellular mucus was not prominent. This case emphasizes the importance of considering malignancy in patients with non‐resolving pulmonary infections. Pathological images of the left lower lobe showing thyroid transcription factor (TTF)‐1 negativity (C) and mucin (MUC)5 AC positivity (D) on immunostaining and no bilayer on p63 staining (E), consistent with the features of ciliated adenocarcinoma.
ISSN:2051-3380
2051-3380
DOI:10.1002/rcr2.1407