Objective evaluation of choroidal melanin loss in patients with Vogt–Koyanagi–Harada disease using polarization-sensitive optical coherence tomography

In this study, sunset glow fundus was evaluated in patients with Vogt–Koyanagi–Harada (VKH) disease using polarization-sensitive optical coherence tomography (PS-OCT). We evaluated 40 VKH eyes (20 patients) and 59 healthy eyes (59 age-matched controls). VKH eyes were divided into three groups accord...

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Published in:Scientific reports 2022-03, Vol.12 (1), p.3526-3526, Article 3526
Main Authors: Miura, Masahiro, Makita, Shuichi, Yasuno, Yoshiaki, Azuma, Shinnosuke, Mino, Toshihiro, Yamaguchi, Tatsuo, Iwasaki, Takuya, Nemoto, Rei, Shimizu, Hiroyuki, Goto, Hiroshi
Format: Article
Language:English
Subjects:
639/624/1107/510
692/308/575
692/699/3161/3177
Choroid - diagnostic imaging
Fluorescein Angiography
Humanities and Social Sciences
Humans
Image processing
Melanin
Melanins
multidisciplinary
Polarization
Retrospective Studies
Science
Science (multidisciplinary)
Tomography
Tomography, Optical Coherence - methods
Uveomeningoencephalitic Syndrome - diagnostic imaging
Visual Acuity
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Summary:In this study, sunset glow fundus was evaluated in patients with Vogt–Koyanagi–Harada (VKH) disease using polarization-sensitive optical coherence tomography (PS-OCT). We evaluated 40 VKH eyes (20 patients) and 59 healthy eyes (59 age-matched controls). VKH eyes were divided into three groups according to color fundus images: sunset (17 eyes), potential sunset (13 eyes), and non-sunset (10 eyes). Choroidal melanin thickness (ChMeT) and the choroidal melanin thickness ratio (ChMeTratio) were calculated based on the degree of polarization uniformity from PS-OCT. ChMeT was significantly lower in sunset eyes than in non-sunset or control eyes (P = 0.003). The ChMeTratios of sunset or potential sunset eyes were significantly lower than those of non-sunset or control eyes (P = 0.04). Regional evaluation of ChMeT and the ChMeTratio showed that choroidal depigmentation predominantly occurred in the macula’s outer ring area (P = 0.002). The areas under receiver operating characteristic curves discriminating combined sunset (sunset and potential sunset) from non-sunset eyes were 0.983 and 0.997 for ChMeT and the ChMeTratio, respectively. Time course evaluation of 12 eyes from disease onset showed that ChMeT and the ChMeTratio significantly decreased over time. PS-OCT may be useful for objectively evaluating choroidal depigmentation in patients with VKH disease.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-07591-9