The rs3918188 and rs1799983 loci of eNOS gene are associated with susceptibility in patients with systemic lupus erythematosus in Northeast China

To investigate the association between single nucleotide polymorphism (SNP) at the rs3918188, rs1799983 and rs1007311 loci of the endothelial nitric oxide synthase ( eNOS ) gene and genetic susceptibility to systemic lupus erythematosus (SLE) in northeastern China. The base distribution of eNOS gene...

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Bibliographic Details
Published in:Scientific reports 2024-09, Vol.14 (1), p.20803-9, Article 20803
Main Authors: Zhang, Xuan, Lin, Guiling, Zhang, Qi, Wu, Huitao, Xu, Wenlu, Wang, Zhe, He, Ziman, Su, Linglan, Zhuang, Yanping, Gong, Aimin
Format: Article
Language:English
Subjects:
692/308/2056
692/4023/1670/1613
Adult
Alleles
Case-Control Studies
China - epidemiology
eNOS
Female
Frequency distribution
Gene Frequency
Gene polymorphism
Genetic analysis
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Haplotypes
Humanities and Social Sciences
Humans
Linkage Disequilibrium
Lupus
Lupus Erythematosus, Systemic - genetics
Male
Middle Aged
Molecular modelling
multidisciplinary
Nitric oxide
Nitric Oxide Synthase Type III - genetics
Nitric-oxide synthase
Northeast China
Peripheral blood
Polymorphism, Single Nucleotide
Regression analysis
Risk factors
Risk reduction
Science
Science (multidisciplinary)
Single nucleotide polymorphism
Susceptibility
Systemic lupus erythematosus
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Summary:To investigate the association between single nucleotide polymorphism (SNP) at the rs3918188, rs1799983 and rs1007311 loci of the endothelial nitric oxide synthase ( eNOS ) gene and genetic susceptibility to systemic lupus erythematosus (SLE) in northeastern China. The base distribution of eNOS gene rs3918188, rs1799983 and rs1007311 in 1712 human peripheral blood samples from Northeast China was detected by SNaPshot sequencing technology. The correlation between genotype, allele and gene model of these loci of the eNOS gene and the genetic susceptibility to SLE was investigated by logistic regression analysis. The results of the differences in the frequency distribution of their gene models were visualised using R 4.3.2 software. Finally, HaploView 4.2 software was used to analyse the relationship between the haplotypes of the three loci mentioned above and the genetic susceptibility to SLE. A multifactor dimensionality reduction (MDR) analysis was used to determine the best SNP-SNP interaction model. The CC genotype and C allele at the rs3918188 locus may be a risk factor for SLE (CC vs AA: OR = 1.827, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-70711-0