Glucosylated caffeoylquinic acid derivatives from the flower buds of Lonicera japonica

Three new glucosylated caffeoylquinic acid isomers(1–3),along with six known compounds,have been isolated from an aqueous extract of the flower buds of Lonicera japonica.Structures of the new compounds were determined by spectroscopic and chemical methods as()-4-O-(4-O-β-D-glucopyranosylcaffeoyl)qui...

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Bibliographic Details
Published in:Acta pharmaceutica Sinica. B 2015-05, Vol.5 (3), p.210-214
Main Authors: Yu, Yang, Jiang, Zhibo, Song, Weixia, Yang, Yongchun, Li, Yuhuan, Jiang, Jiandong, Shi, Jiangong
Format: Article
Language:English
Subjects:
Caprifoliaceae
Coxsackie virus B3
Flower buds
Glucosylated caffeoylquinic acid
Lonicera japonica
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Summary:Three new glucosylated caffeoylquinic acid isomers(1–3),along with six known compounds,have been isolated from an aqueous extract of the flower buds of Lonicera japonica.Structures of the new compounds were determined by spectroscopic and chemical methods as()-4-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(1),()-3-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(2),and()-5-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(3),respectively.In the preliminary in vitro assays,two known compounds methyl caffeate and 2?-O-methyladenosine showed inhibitory activity against Coxsackie virus B3 with IC50 values of 3.70 μmol/L and 6.41 μmol/L and SI values of 7.8 and 12.1,respectively.
ISSN:2211-3835
2211-3843
DOI:10.1016/j.apsb.2015.01.012