Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation

[...]there is strong scientific and clinical need to prepare novel forms of piroxicam possessing modified solubility and dissolution rate which can be formulated for oral administration. [...]aim of the present study was to prepare pharmaceutical cocrystal of piroxicam, formulation of orodispersible...

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Bibliographic Details
Published in:Advanced pharmaceutical bulletin 2017-09, Vol.7 (3), p.399-408
Main Authors: Panzade, Prabhakar, Shendarkar, Giridhar, Shaikh, Sarfaraj, Balmukund Rathi, Pavan
Format: Article
Language:English
Subjects:
Acids
Aluminum
Arthritis
Bioavailability
Cocrystal
Crystallization
Dissolution
Drugs
Factorial design
Orodispersible tablet
Pharmaceutical industry
Piroxicam
Sodium
Solubility
Spectrum analysis
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Summary:[...]there is strong scientific and clinical need to prepare novel forms of piroxicam possessing modified solubility and dissolution rate which can be formulated for oral administration. [...]aim of the present study was to prepare pharmaceutical cocrystal of piroxicam, formulation of orodispersible tablets containing piroxicam cocrystal and its evaluation.13-20 Materials and Methods Piroxicam was gift sample from the Shreya Life sciences Aurangabad (India). [...]the changes recorded in the study can be taken as a signal of the cocrystal formation between the drug and coformers.34 Differential scanning calorimetry Piroxicam, sodium acetate and piroxicam-sodium acetate cocrystal were characterized by DSC. [...]greater dissolution of piroxicam from cocrystal can be attributed to changed crystallinity pattern, size and shape and crystal habit of cocrystal that lead to enhanced solubility of cocrystal in the dissolution media.
ISSN:2228-5881
2251-7308
DOI:10.15171/apb.2017.048