Evaluation of the leishmanicidal and cytotoxic potential of essential oils derived from ten colombian plants

The leishmanicidal and cytotoxic activity of ten essential oils obtained from ten plant specimens were evaluated. Essential oils were obtained by the steam distillation of plant leaves without any prior processing. Cytotoxicity was tested on J774 macrophages and leishmanicidal activity was assessed...

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Bibliographic Details
Published in:Iranian journal of parasitology 2013-01, Vol.8 (1), p.129-136
Main Authors: Sanchez-Suarez, Jf, Riveros, I, Delgado, G
Format: Article
Language:English
Subjects:
Antileishmanial Properties
Colombia
Cytotoxicity
Essential Oils
Leishmania
Natural products
Original
Parasites
Parasitic diseases
Plant
Studies
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Summary:The leishmanicidal and cytotoxic activity of ten essential oils obtained from ten plant specimens were evaluated. Essential oils were obtained by the steam distillation of plant leaves without any prior processing. Cytotoxicity was tested on J774 macrophages and leishmanicidal activity was assessed against four species of Leishmania associated with cutaneous leishmaniasis. Seven essential oils exhibited activity against Leishmania parasites, five of which were toxic against J774 macrophages. Selectivity indices of >6 and 13 were calculated for the essential oils of Ocimum basilicum and Origanum vulgare, respectively. The essential oil of Ocimum basilicum was active against promastigotes of Leishmania and innocuous to J774 macrophages at concentrations up to 1600 µg/mL and should be further investigated for leishmanicidal activity in others in vitro and in vivo experimental models.
ISSN:1735-7020
2008-238X