Feasible kidney donation with living marginal donors, including diabetes mellitus

• Published in: Immunity, Inflammation and Disease Inflammation and Disease, 2021-09, Vol.9 (3), p.1061-1068
• Main Authors: Yoshinaga, Kasumi, Araki, Motoo, Wada, Koichiro, Sekito, Takanori, Watari, Shogo, Maruyama, Yuki, Mitsui, Yosuke, Sadahira, Takuya, Kubota, Risa, Nishimura, Shingo, Edamura, Kohei, Kobayashi, Yasuyuki, Tanabe, Katsuyuki, Takeuchi, Hidemi, Kitagawa, Masashi, Kitamura, Shinji, Wada, Jun, Watanabe, Masami, Watanabe, Toyohiko, Nasu, Yasutomo
• Format: Article
• Language: English
• Subjects: Age; Antihypertensives; Blood pressure; Body mass index; Creatinine; Diabetes; diabetes mellitus; Hemoglobin; Hypertension; Kidney diseases; kidney function; kidney transplantation; Kidney transplants; marginal donor; Marital status; Oral administration; Original; Urine
• ISSN: 2050-4527; 2050-4527
• DOI: 10.1002/iid3.470

Objectives To compare the donor outcomes of living donor kidney transplantation between standard donors (SDs) and marginal donors (MDs) including diabetic patients (MD + DM). Methods MDs were defined according to Japanese guideline criteria: (a) age >70‐years, (b) blood pressure ≤130/80 mmHg on hypertension medicine, (c) body mass index >25 to ≤32 kg/m2, (d) 24‐h creatinine clearance ≥70 to  6.2 or ≤6.5 with oral diabetic medicine. Fifty‐three of 114 donors were MDs. We compared donor kidney functions until 60 months postoperatively. Results No kidney function parameters were different between SDs and MDs. When comparing SD and MD + DM, MD + DM had a lower postoperative eGFR (48 vs. 41 (1 (month), p = .02), 49 vs. 40 (12, p