Comparison of the analgesic effects of oxycodone vs. sufentanil on postoperative pain after laparoscopic gallbladder-preserving cholecystolithotomy: a prospective randomized controlled trial

• Published in: Frontiers in surgery 2024-04, Vol.11, p.1382759-1382759
• Main Authors: Wang, Ye, Wu, Meng, Zhao, Lin, Yan, Xiaojian, Zhao, Lei
• Format: Article
• Language: English
• Subjects: inflammatory factors; laparoscopic gallbladder-preserving cholecystolithotomy; oxycodone; postoperative pain; sufentanil; Surgery
• ISSN: 2296-875X; 2296-875X
• DOI: 10.3389/fsurg.2024.1382759

We aimed to compare the anesthesia induction effects of oxycodone and sufentanil on postoperative pain in patients undergoing laparoscopic gallbladder-preserving cholecystolithotomy, as well as changes in serum levels of inflammatory factors (TNF-α, IL-6, and IL-10) in the perioperative period. Sixty patients who underwent laparoscopic gallbladder-preserving cholecystolithotomy were evenly divided into oxycodone (O) and sufentanil (S) groups. In groups O and S, oxycodone (0.3 mg/kg) and sufentanil (0.3 ug/kg) were administered, respectively, followed by propofol (2 mg/kg) and rocuronium (0.6 mg/kg). In both groups, the intraoperative electroencephalography double-frequency index was used to guide the use of sedative and analgesic drugs, assessing the follow-up analgesic effect (VAS), degree of sedation (Ramsey), and postoperative complications at seven different time points (0, 0.5, 2, 4, 6, 8, and 24 h postoperatively). Compared with the S group, patients in the O group exhibited lower VAS scores within 24 h postoperatively (   0.05). Regarding postoperative awakening and extubation duration, O group patients experienced shorter times and better remedial analgesia (