Three new lignan glucosides from the roots of Scutellaria baicalensis

• Published in: Acta pharmaceutica Sinica. B 2016-05, Vol.6 (3), p.229-233
• Main Authors: Long, Hailin, Zhang, Haijing, Deng, Anjun, Ma, Lin, Wu, Lianqiu, Li, Zhihong, Zhang, Zhihui, Wang, Wenjie, Jiang, Jiandong, Qin, Hailin
• Format: Article
• Language: English
• Subjects: 3,4-Dibenzyltetrahydrofuran; activity; activity; Anti-osteoporotic; Anti-osteoporotic activity; A–C; 3; 4-Dibenzyltetrahydrofuran; Osteoprotegerin-activating; Baicalensinosides A–C; baicalensis; Roots; Labiatae; Lignan; glucoside; Baicalensinosides; Labiatae; Lignan glucoside; Original; Osteoprotegerin-activating activity; Roots; Scutellaria; Scutellaria baicalensis
• ISSN: 2211-3835; 2211-3843
• DOI: 10.1016/j.apsb.2016.03.007

Three new lignan glucosides, baicalensinosides A–C(1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofurantype lignan glycoside with a mono-hydroxyl substitution at the 70-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin(OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.