Comparison of Antimicrobial Activity against Porphyromonas gingivalis between Advanced Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin

Platelet-rich fibrin (PRF) obtained via low-speed centrifugation has antimicrobial properties. This study was conducted to evaluate the effectiveness of advanced platelet-rich fibrin plus (A-PRF+) and injectable platelet-rich fibrin (I-PRF), obtained from patients with different periodontal states,...

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Bibliographic Details
Published in:International journal of biomaterials 2023-03, Vol.2023, p.9194868-7
Main Author: Pham, Thuy Anh Vu
Format: Article
Language:English
Subjects:
Analysis
Antibacterial activity
Antibiotics
Anticoagulants
Antimicrobial activity
Antimicrobial agents
Bacteria
Biofilms
Blood platelets
Centrifugation
Dental plaque
Disease
Ethanol
Fibrin
Gingiva
Gingivitis
Growth factors
Infections
Kinetics
Leukocytes
Low speed
Patients
Periodontics
Periodontitis
Platelets
Porphyromonas gingivalis
Proteins
Stains & staining
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Summary:Platelet-rich fibrin (PRF) obtained via low-speed centrifugation has antimicrobial properties. This study was conducted to evaluate the effectiveness of advanced platelet-rich fibrin plus (A-PRF+) and injectable platelet-rich fibrin (I-PRF), obtained from patients with different periodontal states, against Porphyromonas gingivalis. A-PRF+ and I-PRF samples were obtained from venous blood of 60 subjects divided equally into three groups: periodontitis, gingivitis, and healthy gingiva groups. The antibacterial experiments evaluated biofilm inhibition, mature biofilm impact, and time-kill kinetics. The percent reduction in biofilm-growing and mature biofilm bacteria ranged from 39% to 49% and 3% to 7%, respectively. In the time-kill kinetics assay, PRF from the periodontitis group was more effective as an antimicrobial than that from the gingivitis and healthy gingiva group (p
ISSN:1687-8787
1687-8795
DOI:10.1155/2023/9194868