Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus

Myocardial extravascular extracellular volume fraction (Ve) measures quantify diffuse fibrosis not readily detectable by conventional late gadolinium (Gd) enhancement (LGE). Ve measurement requires steady state equilibrium between plasma and interstitial Gd contrast. While a constant infusion produc...

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Bibliographic Details
Published in:Journal of cardiovascular magnetic resonance 2011-03, Vol.13 (1), p.16-16, Article 16
Main Authors: Schelbert, Erik B, Testa, Stephen M, Meier, Christopher G, Ceyrolles, William J, Levenson, Joshua E, Blair, Alexander J, Kellman, Peter, Jones, Bobby L, Ludwig, Daniel R, Schwartzman, David, Shroff, Sanjeev G, Wong, Timothy C
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cardiovascular diseases
Care and treatment
Collagen
Computer Simulation
Contrast Media - administration & dosage
Contrast Media - pharmacokinetics
Diagnosis
Female
Fibrosis
Gadolinium
Health aspects
Heart attacks
Heart Diseases - diagnosis
Heart Diseases - pathology
Heterocyclic Compounds - administration & dosage
Heterocyclic Compounds - pharmacokinetics
Humans
Infusions, Intravenous
Injections, Intravenous
Magnetic resonance imaging
Magnetic Resonance Imaging - instrumentation
Male
Methods
Molecular weight
Monte Carlo Method
Myocardium - pathology
Organometallic Compounds - administration & dosage
Organometallic Compounds - pharmacokinetics
Pennsylvania
Phantoms, Imaging
Predictive Value of Tests
Reproducibility of Results
Studies
Workflow
Young Adult
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Summary:Myocardial extravascular extracellular volume fraction (Ve) measures quantify diffuse fibrosis not readily detectable by conventional late gadolinium (Gd) enhancement (LGE). Ve measurement requires steady state equilibrium between plasma and interstitial Gd contrast. While a constant infusion produces steady state, it is unclear whether a simple bolus can do the same. Given the relatively slow clearance of Gd, we hypothesized that a bolus technique accurately measures Ve, thus facilitating integration of myocardial fibrosis quantification into cardiovascular magnetic resonance (CMR) workflow routines. Assuming equivalence between techniques, we further hypothesized that Ve measures would be reproducible across scans. In 10 volunteers (ages 20-81, median 33 yr, 3 females), we compared serial Ve measures from a single short axis slice from two scans: first, during a constant infusion, and second, 12-50 min after a bolus (0.2 mmol/kg gadoteridol) on another day. Steady state during infusion was defined when serial blood and myocardial T1 data varied
ISSN:1097-6647
1532-429X
1532-429X
DOI:10.1186/1532-429X-13-16