Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases

Aims and Objectives. To evaluate the clinicopathologic features, response to cytoreductive surgery and adjuvant platinum-based chemotherapy with or without paclitaxel. Materials and Methods. A retrospective observational study of 8 women with a histopathologic diagnosis of primary fallopian tube car...

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Bibliographic Details
Published in:TheScientificWorld 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Bafna, U. D., Devi, Uma K., Shobha, K., Ramachandra, Pallavi V., Subbian, Anbukkani, Kundargi, Rajshekar, Rajkumar, Namrata N., Rathod, Praveen S., Shakuntala, P. N., Narayan, Abhilasha
Format: Article
Language:English
Subjects:
Abdomen
Adult
Aged
Ascites
Cancer
Carcinoma - diagnosis
Carcinoma - drug therapy
Carcinoma - surgery
Chemotherapy
Cysts
Diagnosis
Dissection
Fallopian Tube Neoplasms - diagnosis
Fallopian Tube Neoplasms - drug therapy
Fallopian Tube Neoplasms - surgery
Fallopian tubes
Female
Humans
Hysterectomy
Laparotomy
Medical imaging
Middle Aged
Observational studies
Oncology
Ovaries
Pain
Recurrence
Surgery
Treatment Outcome
Tumors
Vagina
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Summary:Aims and Objectives. To evaluate the clinicopathologic features, response to cytoreductive surgery and adjuvant platinum-based chemotherapy with or without paclitaxel. Materials and Methods. A retrospective observational study of 8 women with a histopathologic diagnosis of primary fallopian tube carcinoma (PFTC) from January 2000 to February 2013. Results. 4/8 (50%) of the women were in the early stage and an intraoperative frozen section was 100% effective in identifying fallopian tube carcinoma and then a staging laparotomy was performed. All 4/8 cases in the early stage had received and responded to single agent carboplatin and all are alive without clinical, radiological, or biochemical evidence of recurrence at the end of 2 years and the longest survivor has completed 13 years. Primary optimal cytoreductive surgery was achievable in 3/4 (75%) in advanced disease. All showed response to adjuvant paclitaxel and carboplatin (T+C), but all had succumbed to the disease following recurrence with mean progression-free survival of 19 months (range 15–21 months) and mean overall survival of 27 months (range 22–36 months). Conclusion. The pivotal role played by a frozen section in diagnosing PFTC which is rare needs to be reemphasized, therefore justifying a primary staging laparotomy in an early stage. Prolonged survival observed in this group following an optimum tailored adjuvant single agent carboplatin is worth noting.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2014/630731