Determination of Alkaloids and Flavonoids in Sophora flavescens by UHPLC-Q-TOF/MS

This study is based on UHPLC-Q-TOF/MS and fragment ions to achieve classification and identification of alkaloids and flavonoids in Sophora flavescens. By reviewing the available and relevant literature, the mass fragmentation rules of alkaloids and flavonoids were summarized. 0.1% formic acid water...

Full description

Saved in:
Bibliographic Details
Published in:Journal of analytical methods in chemistry 2021, Vol.2021, p.1-13
Main Authors: Dong, Yaqian, Jia, Guoxiang, Hu, Jingwen, Liu, Hui, Wu, Tingting, Yang, Shenshen, Li, Yubo, Cai, Ting
Format: Article
Language:English
Subjects:
Acetonitrile
Alkaloids
Analysis
Chemical composition
Chinese medicine
Chromatography
Ethanol
Flavonoids
Formic acid
Fragmentation
Gas flow
Ions
Isoflavones
Mass spectrometry
Medicine, Chinese
Quality control
Scientific imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study is based on UHPLC-Q-TOF/MS and fragment ions to achieve classification and identification of alkaloids and flavonoids in Sophora flavescens. By reviewing the available and relevant literature, the mass fragmentation rules of alkaloids and flavonoids were summarized. 0.1% formic acid water (A) and acetonitrile (B) were used as mobile phases. 37 chemical constituents were identified, including 13 alkaloids and 24 flavonoids. This research method offers a complete strategy based on the fragmentation information of characteristic fragment ions and neutral loss obtained by MS/MS to characterize the chemical composition of Sophora flavescens.
ISSN:2090-8865
2090-8873
DOI:10.1155/2021/9915027