Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent

Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.27 (24), p.8786
Main Authors: Nahar, Lutfun, Al-Groshi, Afaf, Kumar, Anil, Sarker, Satyajit D
Format: Article
Language:English
Subjects:
anticancer
Antiinfectives and antibacterials
Antimitotic agents
Antineoplastic agents
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
arbutin
Arbutin - pharmacology
Arbutin - therapeutic use
Biological properties
Brain cancer
Breast cancer
Cancer
Care and treatment
Cell growth
Cervix
Chronic toxicity
Dermatologic agents
Dermatology
distribution
Female
Formulae, receipts, prescriptions
Glucosides
Health aspects
Humans
Hydroquinone
Hydroquinones
Inflammation
Kinases
Liver
Liver cancer
Low level
Natural products
Prostate
Reagents
Review
Skin
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Summary:Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other therapeutically relevant biological properties, e.g., antioxidant, antimicrobial and anti-inflammatory, as well as anticancer potential. This review presents, for the first time, a comprehensive overview of the distribution of arbutin in the plant kingdom and critically appraises its therapeutic potential as an anticancer agent based on the literature published until the end of August 2022, accessed via several databases, e.g., Web of Science, Science Direct, Dictionary of Natural Products, PubMed and Google Scholar. The keywords used in the search were arbutin, cancer, anticancer, distribution and hydroquinone. Published outputs suggest that arbutin has potential anticancer properties against bladder, bone, brain, breast, cervix, colon, liver, prostate and skin cancers and a low level of acute or chronic toxicity.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27248786