Effect of pilocarpine mouthwash on salivary flow

Pilocarpine is a cholinergic agonist that increases salivary flow and has been used to treat xerostomia. Oral intake is the most frequent route of administration. Adverse effects are dose-dependent and include sudoresis, facial blushing and increased urinary frequency. The objective of the present s...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2002-01, Vol.35 (1), p.105-110
Main Authors: Bernardi, R, Perin, C, Becker, F L, Ramos, G Z, Gheno, G Z, Lopes, L R, Pires, M, Barros, H M T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
BIOLOGY
Double-Blind Method
Female
Humans
Male
MEDICINE, RESEARCH & EXPERIMENTAL
Mouth rinsing
Mouthwash
Mouthwashes - pharmacology
Muscarinic Agonists - administration & dosage
Muscarinic Agonists - pharmacology
Pilocarpine
Pilocarpine - administration & dosage
Pilocarpine - pharmacology
Salivation
Salivation - drug effects
Xerostomia
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Summary:Pilocarpine is a cholinergic agonist that increases salivary flow and has been used to treat xerostomia. Oral intake is the most frequent route of administration. Adverse effects are dose-dependent and include sudoresis, facial blushing and increased urinary frequency. The objective of the present study was to evaluate the effects of topical pilocarpine solutions as mouthwashes on salivary flow and their adverse effects on healthy subjects. Forty volunteers received 10 ml 0.5, 1 and 2% pilocarpine solutions or 0.9% saline in a randomized, double-blind, placebo-controlled manner. Salivation was measured before and 45, 60 and 75 min after mouth rinsing for 1 min with 10 ml of saline or pilocarpine solutions. Vital signs were measured and ocular, gastrointestinal and cardiovascular symptoms, anxiety and flushing were estimated using visual analog scales. There was a dose-dependent increase in salivation. Salivation measured after 1 and 2% pilocarpine (1.4 +/- 0.36 and 2.22 +/- 0.42 g, respectively) was significantly (P
ISSN:0100-879X
1414-431X
0100-879X
1414-431X
DOI:10.1590/s0100-879x2002000100015