Identifying novel biomarkers associated with bladder cancer treatment outcomes

Bladder cancer is a complex disease with variable prognosis. Recent investigations into the molecular landscape of bladder cancer have revealed frequent genetic alterations and molecular subtypes with therapeutic implications. Consequently, a shift toward personalized treatment of bladder cancer is...

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Bibliographic Details
Published in:Frontiers in oncology 2023-03, Vol.13, p.1114203
Main Authors: Castaneda, Peris R, Theodorescu, Dan, Rosser, Charles J, Ahdoot, Michael
Format: Article
Language:English
Subjects:
biomarker
bladder cancer
genetic testing
Oncology
targeted therapy
treatment
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Summary:Bladder cancer is a complex disease with variable prognosis. Recent investigations into the molecular landscape of bladder cancer have revealed frequent genetic alterations and molecular subtypes with therapeutic implications. Consequently, a shift toward personalized treatment of bladder cancer is underway. To this end, several biomarkers have been developed and tested in their ability to predict response to treatment in patients with bladder cancer and potentially help direct therapy. We performed a search of recently published PubMed articles using terms "biomarker," "bladder cancer," and the respective treatment discussed (i.e., "neoadjuvant" or "BCG"). In this review, we summarize the latest studies on novel biomarkers in bladder cancer with a focus on those intended to improve risk stratification and treatment selection.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1114203