Overexpression of Annexin A2 promotes proliferation by forming a Glypican 1/c-Myc positive feedback loop: prognostic significance in human glioma

In order to set up a reliable prediction system for the tumor grade and prognosis in glioma patients, we clarify the complicated crosstalk of Annexin A2 (ANXA2) with Glypican 1 (GPC1) and demonstrate whether combined indexes of ANXA2 and GPC1 could improve the prognostic evaluation for glioma patien...

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Bibliographic Details
Published in:Cell death & disease 2021-03, Vol.12 (3), p.261-261, Article 261
Main Authors: Li, Xin, Nie, Shengdan, Lv, Ziyang, Ma, Lingran, Song, Yuxi, Hu, Zhongxu, Hu, Xin, Liu, Zhiqiang, Zhou, Gaoya, Dai, Zhijie, Song, Tao, Liu, Jiajia, Wang, Shan
Format: Article
Language:English
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Antibodies
Biochemistry
Biomedical and Life Sciences
c-Myc protein
Cell Biology
Cell Culture
Cell proliferation
Feedback
Glioma
Glioma cells
Heparan sulfate proteoglycans
Immunohistochemistry
Immunology
Life Sciences
Medical prognosis
mRNA
Myc protein
Prognosis
Spiders
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Summary:In order to set up a reliable prediction system for the tumor grade and prognosis in glioma patients, we clarify the complicated crosstalk of Annexin A2 (ANXA2) with Glypican 1 (GPC1) and demonstrate whether combined indexes of ANXA2 and GPC1 could improve the prognostic evaluation for glioma patients. We found that ANXA2-induced glioma cell proliferation in a c-Myc-dependent manner. ANXA2 increased the expression of GPC1 via c-Myc and the upregulated GPC1 further promoted the c-Myc level, forming a positive feedback loop, which eventually led to enhanced proliferation of glioma cells. Both mRNA and protein levels of ANXA2 were upregulated in glioma tissues and coincided with the overexpression of GPC1. Besides, we utilized tissue microarrays (TMAs) and immunohistochemistry to demonstrate that glioma patients with both high expression of ANXA2 and GPC1 tended to have higher rate of tumor recurrence and shorter overall survival (OS). In conclusion, the overexpression of ANXA2 promotes proliferation of glioma cells by forming a GPC1/c-Myc positive feedback loop, and ANXA2 together with its downstream target GPC1 could be a potential “combination biomarker” for predicting prognosis of glioma patients.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-021-03547-5