Preparation of Calcium Phosphate Compounds on Zirconia Surfaces for Dental Implant Applications

Titanium is widely used in medical implants despite the release of heavy metal ions over long-term use. Zirconia is very close to the color of teeth; however, its biological inertness hinders bonding with bone tissue. Alkaline treatment and coatings of calcium phosphate can be used to enhance bone r...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-06, Vol.23 (12), p.6675
Main Authors: Cheng, Mei-Shuan, Salamanca, Eisner, Lin, Jerry Chin-Yi, Pan, Yu-Hwa, Wu, Yi-Fan, Teng, Nai-Chia, Watanabe, Ikki, Sun, Ying-Sui, Chang, Wei-Jen
Format: Article
Language:English
Subjects:
alkali treatment
Biocompatibility
Biomedical materials
Bone growth
Bone implants
Bones
Calcium compounds
calcium phosphate coating
Calcium Phosphates
Calcium zirconate
Cell differentiation
Coated Materials, Biocompatible - pharmacology
Coatings
Composite materials
Contact angle
Dental Implants
Dental materials
Dental prosthetics
Experiments
Fractures
Grain size
Heavy metals
Hydroxyapatite
Mesenchyme
Metal ions
Octacalcium phosphate
Osseointegration
Osteoblastogenesis
Phosphate coatings
Phosphates
Physical properties
Regeneration
Regeneration (physiology)
Room temperature
Sintering
Stem cells
surface modification
Surface Properties
Surgical implants
Titanium
Titanium - pharmacology
Zirconia
Zirconium
Zirconium dioxide
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Summary:Titanium is widely used in medical implants despite the release of heavy metal ions over long-term use. Zirconia is very close to the color of teeth; however, its biological inertness hinders bonding with bone tissue. Alkaline treatment and coatings of calcium phosphate can be used to enhance bone regeneration adjacent to dental implants. This study examined the effects of alkaline treatment, calcium phosphate coatings, and sintering, on the physical properties of implant material. Our analysis confirmed that the calcium phosphate species were octacalcium phosphate (OCP). The sintering of calcium phosphate was shown to create B-type HAP, which is highly conducive toward the differentiation of mesenchymal stem cells (MSCs) into osteoblasts for the facilitation of bone integration. Conclusions: This study demonstrated the room-temperature fabrication of dental implants with superhydrophilic surfaces to enhance biocompatibility.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23126675