Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats

Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model...

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Bibliographic Details
Published in:TheScientificWorld 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Rao, C. Mallikarjuna, Nayak, Pawan G., Mathew, Geetha, Kovelamudi, Hemalatha, Kondamudi, Phani Krishna, Shenoy, Rekha R.
Format: Article
Language:English
Subjects:
Acetic acid
Acetic Acid - toxicity
Animals
Benzodioxoles - pharmacology
Benzodioxoles - therapeutic use
Care and treatment
Colleges & universities
Colon
Colon - drug effects
Colon - enzymology
Female
Gastrointestinal tract
Health aspects
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - chemically induced
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - enzymology
Peroxidase - metabolism
Phenols - pharmacology
Phenols - therapeutic use
Rats
Rats, Wistar
Rodents
Sesame oil
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Summary:Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods. The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly (P
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2014/802701