Lymphoepithelial Subtype of Oral Squamous Cell Carcinoma: Report of an EBV-Negative Case and Literature Review

Lymphoepithelial carcinoma (LEC) of the oral mucosa is a rare histopathologic subtype of squamous cell carcinoma (SCC), which shares morphologic similarities with nasopharyngeal carcinoma (NPC), non-keratinizing undifferentiated subtype. The admixture of neoplastic epithelial tumor cells and a dense...

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Published in:Dentistry journal 2022-09, Vol.10 (9), p.165
Main Authors: Emfietzoglou, Rodopi, Pettas, Efstathios, Georgaki, Maria, Papadopoulou, Erofili, Theofilou, Vasileios, Papadogeorgakis, Nikolaos, Piperi, Evangelia, Lopes, Marcio, Nikitakis, Nikolaos
Format: Article
Language:English
Subjects:
Blood diseases
Cancer
Case Report
Case reports
EBV
Epithelium
Epstein-Barr virus
Exocrine glands
Granulomas
Human papillomavirus
Larynx
Literature reviews
Lymphatic system
lymphoepithelial carcinoma
Lymphoma
Middle age
minor salivary glands
Mucosa
Nasopharyngeal carcinoma
Oral cancer
Oral carcinoma
oral cavity
Oral squamous cell carcinoma
Radiation therapy
Salivary gland
Salivary glands
Squamous cell carcinoma
surface epithelium
Throat cancer
Tumor cells
Tumors
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Summary:Lymphoepithelial carcinoma (LEC) of the oral mucosa is a rare histopathologic subtype of squamous cell carcinoma (SCC), which shares morphologic similarities with nasopharyngeal carcinoma (NPC), non-keratinizing undifferentiated subtype. The admixture of neoplastic epithelial tumor cells and a dense lymphoplasmacytic infiltrate makes microscopic diagnosis challenging. LEC etiopathogenesis has been variably associated with Epstein–Barr virus (EBV) infection, depending on the specific anatomic location and racial predilection, with a higher incidence in endemic populations. Although described in several subsites of the head and neck region, including the major salivary glands, the oral mucosa is considered an infrequent location for LEC development, deriving either from minor salivary glands (MSGs) or the surface epithelium. Herein, we report a rare case of an EBV-negative LEC arising from the oral surface epithelium, presenting as gingival swelling, and review the pertinent English-language literature, which revealed only 26 previously reported oral LECs. Our case is only the fourth oral LEC originating from the surface epithelium and the first one to affect the gingiva.
ISSN:2304-6767
2304-6767
DOI:10.3390/dj10090165