The Anti-Constipation Effect of Bifidobacterium Longum W11 Is Likely Due to a Key Genetic Factor Governing Arabinan Utilization

Recent investigations have highlighted, both experimentally and clinically, that probiotic strains equipped with arabinofuranosidase, in particular and , favor regular intestinal motility, thus counteracting constipation. By analyzing the gene expression and the proliferative response in the presenc...

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Bibliographic Details
Published in:Microorganisms (Basel) 2024-08, Vol.12 (8), p.1626
Main Authors: Di Pierro, Francesco, Zerbinati, Nicola, Cazzaniga, Massimiliano, Bertuccioli, Alexander, Palazzi, Chiara Maria, Cavecchia, Ilaria, Matera, Mariarosaria, Labrini, Edoardo, Sagheddu, Valeria, Soldi, Sara
Format: Article
Language:English
Subjects:
abfA
abfB
Arabinofuranosidase
arabinofuranoside
Communication
Constipation
Fatty acids
Fermentation
gastrointestinal motility
Gene expression
Genes
Genomes
Glucose
Intestinal motility
Irritable bowel syndrome
Motility
Probiotics
Proteins
Quadratic programming
Rifaximin
Statistical analysis
Strain analysis
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Summary:Recent investigations have highlighted, both experimentally and clinically, that probiotic strains equipped with arabinofuranosidase, in particular and , favor regular intestinal motility, thus counteracting constipation. By analyzing the gene expression and the proliferative response in the presence of arabinan of the probiotic W11, a strain previously validated as an anti-constipation probiotic, we have speculated that its response mechanism to arabinan can effectively explain its clinical action. Our approach could be used in the future to select probiotics endowed with arabinofuranosidase-related anti-constipation effects.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms12081626