Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population

Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the CYP2C9*2 , CYP2C9*3 , CYP2C19*2 , CYP2C19*3 , CYP2C19*6 , CYP2C19*17 , and CYP3A4 (...

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Published in:Scientific reports 2021-06, Vol.11 (1), p.12343-12343, Article 12343
Main Authors: Sukprasong, Rattanaporn, Chuwongwattana, Sumonrat, Koomdee, Napatrupron, Jantararoungtong, Thawinee, Prommas, Santirhat, Jinda, Pimonpan, Rachanakul, Jiratha, Nuntharadthanaphong, Nutthan, Jongjitsook, Nutcha, Puangpetch, Apichaya, Sukasem, Chonlaphat
Format: Article
Language:English
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Alleles
Cytochrome P450
Gene frequency
Genotyping
Humanities and Social Sciences
multidisciplinary
Pharmacogenomics
Phenotypes
Population
Population genetics
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
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Summary:Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the CYP2C9*2 , CYP2C9*3 , CYP2C19*2 , CYP2C19*3 , CYP2C19*6 , CYP2C19*17 , and CYP3A4 (rs4646437) alleles in a Thai population across different regions of Thailand was examined. Tests for polymorphisms of CYP2C9 and CYP3A4 were performed using TaqMan SNP genotyping assay and CYP2C19 was performed using two different methods; TaqMan SNP genotyping assay and Luminex x Tag V3. The blood samples were collected from 1205 unrelated healthy individuals across different regions within Thailand. Polymorphisms of CYP2C9 and CYP2C19 were transformed into phenotypes, which included normal metabolizer (NM), intermediate metabolizer (IM), poor metabolizer (PM), and rapid metabolizers (RM). The CYP2C9 allele frequencies among the Thai population were 0.08% and 5.27% for the CYP2C9*2 and CYP2C9*3 alleles, respectively. The CYP2C19 allele frequencies among the Thai population were 25.60%, 2.50%, 0.10%, and 1.80% for the CYP2C19*2 , CYP2C19*3 , CYP2C19*6 , and CYP2C19*17 alleles, respectively. The allele frequency of the CYP3A4 (rs4646437) variant allele was 28.50% in the Thai population. The frequency of the CYP2C9*3 allele was significantly lower among the Northern Thai population (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-90969-y