A proposed new Japanese classification of synchronous peritoneal metastases from colorectal cancer: A multi‐institutional, prospective, observational study conducted by the Japanese Society for Cancer of the Colon and Rectum

• Published in: Annals of gastroenterological surgery 2023-09, Vol.7 (5), p.765-771
• Main Authors: Kobayashi, Hirotoshi, Kotake, Kenjiro, Kawasaki, Masayasu, Kanemitsu, Yukihide, Kinugasa, Yusuke, Ueno, Hideki, Maeda, Kotaro, Suto, Takeshi, Itabashi, Michio, Funahashi, Kimihiko, Ozawa, Heita, Koyama, Fumikazu, Noura, Shingo, Ishida, Hideyuki, Ohue, Masayuki, Kiyomatsu, Tomomichi, Ishihara, Soichiro, Koda, Keiji, Baba, Hideo, Kawada, Kenji, Hashiguchi, Yojiro, Goi, Takanori, Toiyama, Yuji, Tomita, Naohiro, Sunami, Eiji, Akagi, Yoshito, Watanabe, Jun, Hakamada, Kenichi, Nakayama, Goro, Sugihara, Kenichi, Ajioka, Yoichi
• Format: Article
• Language: English
• Subjects: Chemotherapy; Classification; Colorectal cancer; Gastric cancer; JSCCR; Medical prognosis; Metastasis; Observational studies; Original; peritoneal metastasis; R0 resection; Rectum; Surgery
• ISSN: 2475-0328; 2475-0328
• DOI: 10.1002/ags3.12679

Aim To establish a new Japanese classification of synchronous peritoneal metastases from colorectal cancer. Methods This multi‐institutional, prospective, observational study enrolled patients who underwent surgery for colorectal cancer with synchronous peritoneal metastases. Overall survival rates were compared according to the various models using objective indicators. Each model was evaluated by Akaike's information criterion (AIC). The region of peritoneal metastases was evaluated by the peritoneal cancer index (PCI). Results Between October 2012 and December 2016, 150 patients were enrolled. The AIC of the present Japanese classification was 1020.7. P1 metastasis was defined as confined to two regions. The minimum AIC was obtained with the cutoff number of 10 or less for P2 metastasis and 11 or more for P3 metastasis. As for size, the best discrimination ability between P2 and P3 metastasis was obtained with a cutoff value of 3 cm. The AIC of the proposed classification was 1014.7. The classification was as follows: P0, no peritoneal metastases; P1, metastases localized to adjacent peritoneum (within two regions of PCI); P2, metastases to distant peritoneum, number ≤10 and size ≤3 cm; P3, metastases to distant peritoneum, number ≥11 or size >3 cm; P3a, metastases to distant peritoneum, number ≥11 and size ≤3 cm, or number ≤10 and size >3 cm; P3b, metastases to distant peritoneum, number ≥11 and size >3 cm. Conclusion This objective classification could improve the ability to discriminate prognosis in patients with synchronous peritoneal metastases from colorectal cancer. The present study demonstrated a new objective classification for peritoneal metastasis from colorectal cancer.